Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003196 | 1.00 | HSD11B1 (0.48) | HSD11B1L3MBTL1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL20002255 | 0.87 | CCR5 (0.49) | HSD11B1KMT2A | |
| SCHEMBL20003224 | 0.87 | KMT2A (0.43) | HSD11B1ALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL20002972 | 0.87 | L3MBTL1 (0.41) | HSD11B1L3MBTL1KMT2A | |
| SCHEMBL20003223 | 0.84 | KMT2A (0.41) | HSD11B1ALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL20003024 | 0.81 | NOTUM (0.44) | HSD11B1L3MBTL1ALDH1A1KMT2AEPHX2 | |
| SCHEMBL20002886 | 0.79 | KMT2A (0.40) | HSD11B1ALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL20002297 | 0.78 | NOTUM (0.47) | HSD11B1L3MBTL1KMT2A | |
| SCHEMBL4107783 | 0.77 | ALDH1A1 (0.42) | ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL5472049 | 0.77 | HSD11B1 (0.62) | HSD11B1ALDH1A1KMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |