Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002719 | 0.87 | HSD11B1 (0.48) | KMT2ATSHRALDH1A1PTPN1KEAP1 | |
| SCHEMBL20003196 | 0.87 | HSD11B1 (0.48) | KMT2ATSHRALDH1A1PTPN1KEAP1 | |
| SCHEMBL20003223 | 0.84 | KMT2A (0.41) | KMT2ATSHRALDH1A1PTPN1KEAP1 | |
| SCHEMBL20003227 | 0.75 | KMT2A (0.38) | KMT2ASMN1; SMN2 | |
| SCHEMBL20002255 | 0.74 | CCR5 (0.49) | KMT2AHSD11B1 | |
| SCHEMBL20002972 | 0.74 | L3MBTL1 (0.41) | KMT2AHSD11B1 | |
| SCHEMBL20003069 | 0.69 | RORC (0.42) | KMT2AALDH1A1 | |
| SCHEMBL20003024 | 0.68 | NOTUM (0.44) | KMT2AALDH1A1HSD11B1MEN1 | |
| SCHEMBL20002886 | 0.67 | KMT2A (0.40) | KMT2AALDH1A1HSD11B1SMN1; SMN2 | |
| SCHEMBL20002297 | 0.65 | NOTUM (0.47) | KMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |