Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003196 | 0.87 | HSD11B1 (0.48) | L3MBTL1KMT2AHSD11B1 | |
| SCHEMBL20002719 | 0.87 | HSD11B1 (0.48) | L3MBTL1KMT2AHSD11B1 | |
| SCHEMBL20002297 | 0.81 | NOTUM (0.47) | L3MBTL1MAPTNOTUMRORCKMT2A | |
| SCHEMBL20003024 | 0.81 | NOTUM (0.44) | L3MBTL1MAPTNOTUMKMT2AHSD11B1 | |
| SCHEMBL20002255 | 0.80 | CCR5 (0.49) | RORCKMT2AHSD11B1 | |
| SCHEMBL4107783 | 0.75 | ALDH1A1 (0.42) | MAPTNOTUMKMT2AGRIN1GRIN2B | |
| SCHEMBL20003224 | 0.74 | KMT2A (0.43) | KMT2AHSD11B1 | |
| SCHEMBL20002886 | 0.74 | KMT2A (0.40) | RORCKMT2AHSD11B1GRIN1GRIN2B | |
| SCHEMBL4097076 | 0.74 | CCR5 (0.42) | L3MBTL1NOTUMKMT2AHSD11B1GRIN1 | |
| SCHEMBL20003069 | 0.74 | RORC (0.42) | MAPTNOTUMRORCKMT2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |