Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | USP19 | O94966 | 2/20 | 0.35 |
| ▸ | FASN | P49327 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003055 | 0.76 | RORC (0.42) | RORCHSD11B1KMT2ASMN1; SMN2 | |
| SCHEMBL20003069 | 0.76 | RORC (0.42) | RORCKMT2A | |
| SCHEMBL20002683 | 0.73 | KMT2A (0.39) | RORCHSD11B1KMT2A | |
| SCHEMBL20002823 | 0.70 | CCR5 (0.38) | HSD11B1KMT2ASMN1; SMN2 | |
| SCHEMBL20002294 | 0.68 | PTPN11 (0.36) | RORCKMT2A | |
| SCHEMBL20003154 | 0.67 | RORC (0.39) | RORCHSD11B1KMT2ASMN1; SMN2 | |
| SCHEMBL20002612 | 0.67 | RORC (0.36) | RORCKMT2A | |
| SCHEMBL20003220 | 0.67 | RORC (0.41) | RORCHSD11B1KMT2ASMN1; SMN2 | |
| SCHEMBL29087365 | 0.66 | NPC1 (0.46) | SMN1; SMN2 | |
| SCHEMBL18703632 | 0.65 | GPR119 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |