Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 2/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003069 | 0.86 | RORC (0.42) | KMT2ARORCGFERGRIN2BPIK3CD | |
| SCHEMBL20002736 | 0.73 | RORC (0.36) | KMT2ARORCHSD11B1 | |
| SCHEMBL20002255 | 0.71 | CCR5 (0.49) | KMT2ARORCHSD11B1 | |
| SCHEMBL20003196 | 0.71 | HSD11B1 (0.48) | KMT2AALDH1A1HSD11B1 | |
| SCHEMBL20002719 | 0.71 | HSD11B1 (0.48) | KMT2AALDH1A1HSD11B1 | |
| SCHEMBL20002886 | 0.67 | KMT2A (0.40) | KMT2ARORCGRIN2BALDH1A1HSD11B1 | |
| SCHEMBL20003224 | 0.66 | KMT2A (0.43) | KMT2AALDH1A1HSD11B1 | |
| SCHEMBL20003152 | 0.66 | RAB9A (0.34) | KMT2AGRIN2BALDH1A1MAPTHSD11B1 | |
| SCHEMBL20002684 | 0.65 | L3MBTL1 (0.47) | RORCALDH1A1MAPTGAAKDM4E | |
| SCHEMBL20002927 | 0.65 | ALDH1A1 (0.46) | RORCGFERALDH1A1HSD11B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |