Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003130 | 0.82 | ALDH1A1 (0.49) | MAPTRORCKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20002762 | 0.80 | ALDH1A1 (0.44) | MAPTRORCKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20003072 | 0.79 | RORC (0.43) | MAPTRORCALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20003196 | 0.71 | HSD11B1 (0.48) | EPHX2ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL20002719 | 0.71 | HSD11B1 (0.48) | EPHX2ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL19702601 | 0.71 | MAPT (0.55) | MAPTCYP2C9ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL30730587 | 0.71 | MAPK1 (0.43) | MAPTRORCALDH1A1NAMPTKMT2A | |
| SCHEMBL19703195 | 0.70 | SMN1; SMN2 (0.52) | MAPTCYP2C9ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL20002255 | 0.69 | CCR5 (0.49) | RORCKMT2A | |
| SCHEMBL20002879 | 0.69 | NPC1 (0.44) | ALDH1A1SMN1; SMN2KMT2ARAB9AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |