Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.75 |
| ▸ | HTR1A | P08908 | 5/20 | 0.75 |
| ▸ | HTR2A | P28223 | 5/20 | 0.75 |
| ▸ | HTR2B | P41595 | 5/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.75 |
| ▸ | HTR1D | P28221 | 4/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.75 |
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.75 |
| ▸ | HTR1B | P28222 | 2/20 | 0.75 |
| ▸ | HTR7 | P34969 | 2/20 | 0.75 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.75 |
| ▸ | HTR3B | O95264 | 1/20 | 0.75 |
| ▸ | DRD1 | P21728 | 1/20 | 0.75 |
| ▸ | HTR1E | P28566 | 1/20 | 0.75 |
| ▸ | HTR1F | P30939 | 1/20 | 0.75 |
| ▸ | DRD3 | P35462 | 1/20 | 0.75 |
| ▸ | RECQL | P46063 | 1/20 | 0.75 |
| ▸ | HTR3A | P46098 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serotonin SCHEMBL1495 | 0.86 | HTR2C (1.00) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| Serotonin SCHEMBL30057954 | 0.86 | HTR2C (1.00) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| Serotonin SCHEMBL183226 | 0.86 | HTR2C (1.00) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| Serotonin SCHEMBL29349412 | 0.86 | HTR2C (1.00) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| SCHEMBL5424801 | 0.85 | HTR2C (0.71) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| Serotonin SCHEMBL25341783 | 0.84 | HTR2C (1.00) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| Serotonin SCHEMBL3091827 | 0.84 | HTR2C (0.97) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| Serotonin SCHEMBL396997 | 0.84 | HTR2C (0.97) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| Serotonin SCHEMBL1675866 | 0.84 | HTR2C (0.97) | HTR2CHTR1AHTR2AHTR2BCYP2D6 | |
| Serotonin SCHEMBL29781387 | 0.84 | HTR2C (1.00) | HTR2CHTR1AHTR2AHTR2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| EP-0240352-B1 | 5-FLUOROURACIL DERIVATIVES AND PROCESSES FOR PRODUCING THEREOF | Chisso Corporation (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-4792607-A | ANTICANCER MEDICINE INTERRMEDIATES | CHISSO CORPORATION (JP) | 1988-12-20 | — | — | US | disclosed |
| EP-0240352-A2 | 5-Fluorouracil derivatives and processes for producing thereof | Chisso Corporation (JP) | 1987-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | HTR2C 13/4885HTR1A 22/4885HTR2A 18/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | HTR2C 46/4885HTR1A 39/4885HTR2A 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.