Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GALR2 | O43603 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008830 | 0.87 | RAF1 (0.34) | CRHR1RAF1BRAF | |
| SCHEMBL20008765 | 0.83 | PDE1B (0.33) | L3MBTL1MAPK1LMNACRHR1ALDH1A1 | |
| SCHEMBL20008319 | 0.78 | — | — | |
| SCHEMBL20008538 | 0.72 | DRD2 (0.49) | L3MBTL1MAPK1ATMSMN1; SMN2LMNA | |
| SCHEMBL20010275 | 0.71 | — | — | |
| SCHEMBL20008122 | 0.71 | SMN1; SMN2 (0.46) | L3MBTL1MAPK1ATMSMN1; SMN2LMNA | |
| SCHEMBL19529392 | 0.69 | RAF1 (0.40) | L3MBTL1MAPK1ATMSMN1; SMN2LMNA | |
| SCHEMBL20008452 | 0.69 | GALR2 (0.44) | L3MBTL1MAPK1ATMSMN1; SMN2LMNA | |
| SCHEMBL20008460 | 0.68 | RAF1 (0.41) | L3MBTL1MAPK1ATMSMN1; SMN2LMNA | |
| SCHEMBL20008434 | 0.67 | CRHR1 (0.34) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |