Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 3/20 | 0.33 |
| ▸ | NMT1 | P30419 | 3/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008457 | 0.83 | L3MBTL1 (0.34) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL20010275 | 0.71 | — | — | |
| SCHEMBL20008830 | 0.70 | RAF1 (0.34) | CRHR1 | |
| SCHEMBL20009409 | 0.69 | RAF1 (0.45) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL20008434 | 0.68 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL7718046 | 0.64 | SMN1; SMN2 (0.43) | KDM4EALDH1A1LMNATSHRCRHR1 | |
| SCHEMBL15730626 | 0.63 | CNR2 (0.64) | KDM4ECNR2 | |
| SCHEMBL25925332 | 0.60 | AGTR1 (0.36) | CRHR1L3MBTL1KMT2A | |
| SCHEMBL23916149 | 0.60 | S1PR1 (0.32) | CRHR1 | |
| SCHEMBL20008328 | 0.59 | CNR2 (0.48) | KDM4EALDH1A1HPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |