Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 4/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18745826 | 0.87 | LOXL2 (0.49) | NOS3NOS2ADRB2ALDH1A1GAA | |
| SCHEMBL20122650 | 0.86 | LOXL2 (0.34) | NOS3NOS2ADRB2ALDH1A1GAA | |
| SCHEMBL18532052 | 0.85 | LMNA (0.35) | ALDH1A1L3MBTL1MAPK1NPSR1CYP2D6 | |
| SCHEMBL2609325 | 0.81 | NOS3 (0.53) | NOS3NOS2ADRB2ALDH1A1GAA | |
| SCHEMBL18699091 | 0.81 | MAPK1 (0.36) | ALDH1A1MAPK1NPSR1 | |
| SCHEMBL18532099 | 0.79 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MAPK1NPSR1 | |
| SCHEMBL15693563 | 0.79 | NOS3 (0.41) | NOS3NOS2ADRB2ALDH1A1GAA | |
| SCHEMBL2327508 | 0.78 | NOS3 (0.59) | NOS3NOS2ADRB2ALDH1A1GAA | |
| SCHEMBL18415080 | 0.78 | LOXL2 (0.34) | ALDH1A1LOXL2LOXMAPK1RORC | |
| SCHEMBL22903529 | 0.76 | SMN1; SMN2 (0.38) | ADRB2ALDH1A1L3MBTL1ARMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11655239-B2 | Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof | Shanghai Institute of Material Medica, Chinese Academy of Sciences (CN) | 2023-05-23 | — | — | US | disclosed |
| US-11242332-B2 | Method for producing benzimidazole derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2022-02-08 | — | — | US | disclosed |
| US-20200347071-A1 | AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-11-05 | — | — | US | disclosed |
| US-20200071295-A1 | METHOD FOR PRODUCING BENZIMIDAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2020-03-05 | — | — | US | disclosed |
| US-20180094010-A1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | NEWGEN THERAPEUTICS INC (US) | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347071-A1 | AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS | RIPK1, RIPK2, RIPK4 | NOS3 1952/4885NOS2 1418/4885ADRB2 2899/4885 |
| US-20180094010-A1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | PARP1, PARP2, PARP11 | NOS3 3346/4885NOS2 3333/4885ADRB2 4547/4885 |
| US-11242332-B2 | Method for producing benzimidazole derivative | CYP3A4, CYP3A5, CYP3A43 | NOS3 1576/4885NOS2 1072/4885ADRB2 1562/4885 |
| US-20200071295-A1 | METHOD FOR PRODUCING BENZIMIDAZOLE DERIVATIVE | CYP3A4, CYP3A5, CYP3A43 | NOS3 1576/4885NOS2 1072/4885ADRB2 1562/4885 |
| US-11655239-B2 | Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof | DDR2, DDR1, DOCK2 | NOS3 2362/4885NOS2 686/4885ADRB2 917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.