Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25150346 | 0.83 | P2RX7 (0.39) | P2RX7MEN1LMNAKMT2AELANE | |
| SCHEMBL25150547 | 0.82 | NR1I2 (0.50) | P2RX7MEN1LMNAKMT2AELANE | |
| SCHEMBL20037747 | 0.81 | MEN1 (0.40) | P2RX7MEN1LMNAKMT2AELANE | |
| SCHEMBL23875385 | 0.81 | P2RX7 (0.36) | P2RX7MEN1LMNAKMT2AELANE | |
| SCHEMBL24501868 | 0.81 | KMT2A (0.41) | P2RX7MEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL6745604 | 0.81 | KMT2A (0.41) | P2RX7MEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL13003596 | 0.81 | KMT2A (0.41) | P2RX7MEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL23104725 | 0.80 | P2RX7 (0.41) | P2RX7MEN1LMNAKMT2AHDAC6 | |
| SCHEMBL2674305 | 0.79 | SLC6A4 (0.46) | P2RX7MEN1LMNAKMT2AADRA2A | |
| SCHEMBL12352043 | 0.79 | LMNA (0.47) | P2RX7MEN1LMNAKMT2AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10946018-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | ROIVANT SCIENCES GMBH (CH) | 2021-03-16 | — | — | US | disclosed |
| US-20200237760-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | ROIVANT SCIENCES GMBH (CH) | 2020-07-30 | — | — | US | disclosed |
| US-10292394-B2 | Herbicidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2019-05-21 | — | — | US | disclosed |
| US-20180110225-A1 | HERBICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-04-26 | — | — | US | disclosed |
| US-20180092918-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200237760-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | TPH1, TPH2, HTR1A | P2RX7 1521/4885MEN1 629/4885LMNA 2851/4885 |
| US-20180092918-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | TPH1, TPH2, HTR1A | P2RX7 1521/4885MEN1 629/4885LMNA 2851/4885 |
| US-20180110225-A1 | HERBICIDAL COMPOUNDS | DDT, HPD, DDC | P2RX7 902/4885MEN1 4743/4885LMNA 3150/4885 |
| US-10292394-B2 | Herbicidal compounds | DDT, HPD, DDC | P2RX7 902/4885MEN1 4743/4885LMNA 3150/4885 |
| US-10946018-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | TPH1, TPH2, HTR1A | P2RX7 1521/4885MEN1 629/4885LMNA 2851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.