SCHEMBL6745604

SCHEMBL6745604

CCC(C)c1ccc(C)nc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.41
MEN1 O00255 3/20 0.41
LMNA P02545 1/20 0.41
ALDH1A1 P00352 4/20 0.40
CYP2C9 P11712 2/20 0.40
TSHR P16473 1/20 0.40
HPGD P15428 2/20 0.39
USP2 O75604 1/20 0.39
GAA P10253 1/20 0.39
PKM P14618 1/20 0.39
ALOX15 P16050 1/20 0.39
HSD17B10 Q99714 1/20 0.39
RAB9A P51151 4/20 0.39
NPC1 O15118 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24501868 1.00 KMT2A (0.41) KMT2AMEN1LMNAALDH1A1CYP2C9
SCHEMBL13003596 1.00 KMT2A (0.41) KMT2AMEN1LMNAALDH1A1CYP2C9
SCHEMBL18927429 0.84 KMT2A (0.40) KMT2AMEN1LMNACYP1A2CYP2C19
SCHEMBL21275431 0.82 TAAR1 (0.47) KMT2AMEN1LMNACYP1A2CYP2C19
SCHEMBL29640790 0.82 TAAR1 (0.47) KMT2AMEN1LMNACYP1A2CYP2C19
SCHEMBL23242089 0.82 TAAR1 (0.47) KMT2AMEN1LMNACYP1A2CYP2C19
SCHEMBL14217551 0.82 TAAR1 (0.47) KMT2AMEN1LMNACYP1A2CYP2C19
SCHEMBL20718221 0.81 KMT2A (0.38) KMT2AMEN1LMNAP2RX7HRH1
SCHEMBL20032334 0.81 P2RX7 (0.40) KMT2AMEN1LMNACYP1A2CYP2C19
SCHEMBL20389049 0.80 KMT2A (0.37) KMT2AMEN1LMNAP2RX7HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043607-B2 HDAC inhibitors and therapeutic use thereof TANGO THERAPEUTICS, INC. (US) 2024-07-23 US disclosed
US-20230183226-A1 AKT3 MODULATORS Georgiamune Inc. 2023-06-15 US disclosed
US-20230174501-A1 NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF TANGO THERAPEUTICS, INC. 2023-06-08 US disclosed
EP-2970155-B1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO) BRISTOL MYERS SQUIBB CO (US) 2018-04-25 EP disclosed
US-20170362234-A1 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-12-21 US disclosed
US-9750740-B2 Spirocyclic compounds as tryptophan hydroxylase inhibitors Kanos Pharmaceuticals, Inc. (US) 2017-09-05 US disclosed
US-20170095476-A1 SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS ALTAVANT SCIENCES GMBH (CH) 2017-04-06 US disclosed
US-20120232048-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2012-09-13 US disclosed
US-20120232048-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2012-09-13 US disclosed
US-8178561-B2 Method for modulating GPR119 G protein-coupled receptor and selected compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2012-05-15 US disclosed
EP-2173737-B1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2012-01-11 EP disclosed
US-20110190327-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2011-08-04 US disclosed
US-20110190327-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2011-08-04 US disclosed
US-7928230-B2 Method for modulating GPR119 G protein-coupled receptor and selected compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2011-04-19 US disclosed
US-7928230-B2 Method for modulating GPR119 G protein-coupled receptor and selected compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2011-04-19 US disclosed
WO-2010149684-A1 NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-12-29 WO disclosed
US-20100323887-A1 MESOIONIC PESTICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-12-23 US disclosed
US-20090042919-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2009-02-12 US disclosed
US-20090042919-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2009-02-12 US disclosed
WO-2009012277-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110190327-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS GPR119, GPR65, GPR84 KMT2A 3559/4885MEN1 2862/4885LMNA 4695/4885
US-20230183226-A1 AKT3 MODULATORS AKT3, AKT2, MTOR KMT2A 3974/4885MEN1 1948/4885LMNA 1249/4885
US-20120232048-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS GPR119, GPR65, GPR84 KMT2A 3559/4885MEN1 2862/4885LMNA 4695/4885
US-20170095476-A1 SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS TPH1, TPH2, HTR1A KMT2A 1610/4885MEN1 629/4885LMNA 2851/4885
US-20230174501-A1 NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF HDAC1, HDAC7, HDAC5 KMT2A 110/4885MEN1 4054/4885LMNA 1237/4885
US-20090042919-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS GPR119, GPR65, GPR84 KMT2A 3559/4885MEN1 2862/4885LMNA 4695/4885
US-20100323887-A1 MESOIONIC PESTICIDES DDT, CHRM1, CHRM3 KMT2A 3136/4885MEN1 255/4885LMNA 4228/4885
US-20170362234-A1 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS SIRT1, SIRT3, SIRT2 KMT2A 1870/4885MEN1 3209/4885LMNA 3512/4885
US-12043607-B2 HDAC inhibitors and therapeutic use thereof HDAC1, HDAC7, HDAC5 KMT2A 97/4885MEN1 3551/4885LMNA 776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.