Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006172 | 0.93 | ALOX5AP (0.39) | KDM4ESMN1; SMN2ALOX5ALOX5APMAPT | |
| SCHEMBL2002932 | 0.92 | PLA2G2A (0.43) | ALDH1A1ACHEPLA2G2AMAPTCYP3A4 | |
| SCHEMBL2002482 | 0.92 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2ALOX5 | |
| SCHEMBL2003941 | 0.92 | P2RX7 (0.38) | ALDH1A1KDM4EHPGDMAPTCYP3A4 | |
| SCHEMBL2003542 | 0.92 | MAPT (0.39) | ALDH1A1ALOX5ALOX5APACHEPLA2G2A | |
| SCHEMBL2010168 | 0.91 | ALOX5AP (0.38) | ALDH1A1KDM4EHPGDSMN1; SMN2ALOX5 | |
| SCHEMBL1996791 | 0.90 | PTGES2 (0.38) | ALDH1A1KDM4EHPGDSMN1; SMN2ALOX5AP | |
| SCHEMBL2002287 | 0.89 | L3MBTL1 (0.39) | ALDH1A1KDM4EHPGDSMN1; SMN2ALOX5 | |
| SCHEMBL2008737 | 0.89 | LMNA (0.42) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL2004073 | 0.89 | KDM4E (0.41) | ALDH1A1KDM4EHPGDSMN1; SMN2TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |