Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994785 | 0.89 | TNIK (0.38) | ADORA2ADRD2DRD4DRD3USP7 | |
| SCHEMBL1998214 | 0.89 | LMNA (0.37) | ALDH1A1LMNAGAAADORA2ASCN9A | |
| SCHEMBL1998836 | 0.84 | HTR2C (0.39) | HTR1AHTR7ADORA2ASCN9AADORA1 | |
| SCHEMBL5224744 | 0.83 | HTR1A (0.38) | HTR1AHTR7NR1H2ACVR1ALDH1A1 | |
| SCHEMBL1998680 | 0.81 | HTR7 (0.39) | HTR1AHTR7ALDH1A1ADORA2ADRD2 | |
| SCHEMBL1998525 | 0.81 | HTR7 (0.39) | HTR1AHTR7ALDH1A1LMNAADORA2A | |
| SCHEMBL5226838 | 0.78 | ALDH1A1 (0.41) | ACVR1ALDH1A1LMNAGAA | |
| SCHEMBL5227547 | 0.77 | PDCD1 (0.43) | ACVR1ALDH1A1LMNAGAAADORA2A | |
| SCHEMBL1999584 | 0.76 | SMO (0.38) | ALDH1A1LMNAGAAADORA2ADRD2 | |
| SCHEMBL1995720 | 0.76 | SMO (0.38) | ALDH1A1LMNAGAADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960413-B2 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2011-06-14 | — | — | US | disclosed |
| EP-1611094-B1 | PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-20 | — | — | EP | disclosed |
| US-20060276650-A1 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276650-A1 | Pyrazole compounds | HTR1D, HTR1A, HTR3A | HTR1A 2/4885HTR7 16/4885NR1H2 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.