Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 4/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042872 | 0.87 | P2RX7 (0.44) | P2RX7CHRM4LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL20042652 | 0.87 | P2RX7 (0.66) | P2RX7LMNASMN1; SMN2ABL1BCR | |
| SCHEMBL20042760 | 0.87 | P2RX7 (0.45) | P2RX7PKMABL1BCR | |
| SCHEMBL20042704 | 0.84 | P2RX7 (0.50) | P2RX7SMN1; SMN2ABL1BCRSLC6A7 | |
| SCHEMBL20042697 | 0.84 | PROKR1 (0.48) | P2RX7CHRM2CHRM4LMNASMN1; SMN2 | |
| SCHEMBL20042701 | 0.84 | PROKR1 (0.47) | P2RX7CHRM4LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL20042666 | 0.82 | KMT2A (0.46) | P2RX7 | |
| SCHEMBL20042702 | 0.82 | P2RX7 (0.49) | P2RX7SMN1; SMN2HSD17B10 | |
| SCHEMBL20042671 | 0.82 | P2RX7 (0.45) | P2RX7SMN1; SMN2 | |
| SCHEMBL31614786 | 0.82 | CHRM4 (0.52) | P2RX7CHRM2CHRM4GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |