Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042863 | 0.92 | GRM5 (0.42) | P2RX7NPY5RGBA1GRM5KCNH2 | |
| SCHEMBL20042713 | 0.90 | GRM5 (0.45) | P2RX7GRM5HPGDKDM4ETSHR | |
| SCHEMBL20042684 | 0.89 | SMN1; SMN2 (0.52) | P2RX7SMN1; SMN2HTTGRM5KCNH2 | |
| SCHEMBL20042685 | 0.88 | HTT (0.42) | P2RX7SMN1; SMN2GBA1HTTGRM5 | |
| SCHEMBL20042743 | 0.88 | P2RX7 (0.40) | P2RX7SMN1; SMN2GBA1HPGDCNR1 | |
| SCHEMBL20042689 | 0.86 | P2RX7 (0.39) | P2RX7SMN1; SMN2GBA1GRM5CNR2 | |
| SCHEMBL20042666 | 0.85 | KMT2A (0.46) | P2RX7GBA1GRM5KCNH2CNR1 | |
| SCHEMBL20042823 | 0.84 | P2RX7 (0.45) | P2RX7GBA1HTTHPGDCNR1 | |
| SCHEMBL20042836 | 0.84 | P2RX7 (0.43) | P2RX7SMN1; SMN2GBA1HTTHPGD | |
| SCHEMBL20042769 | 0.84 | P2RX7 (0.38) | P2RX7GBA1CNR1CNR2GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |