Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | MAPK7 | Q13164 | 5/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PRLHR | P49683 | 2/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042707 | 0.87 | P2RX7 (0.40) | EPHX2MAPK7P2RX7MGLLTRPM8 | |
| SCHEMBL20042704 | 0.86 | P2RX7 (0.50) | EPHX2P2RX7 | |
| SCHEMBL20042796 | 0.86 | P2RX7 (0.38) | P2RX7LMNATP53 | |
| SCHEMBL20042694 | 0.85 | P2RX7 (0.43) | MAPK7P2RX7MGLLPRLHR | |
| SCHEMBL20042780 | 0.85 | P2RX7 (0.43) | EPHX2MAPK7HRH3P2RX7MGLL | |
| SCHEMBL20042861 | 0.85 | P2RX7 (0.39) | MAPK7P2RX7MGLL | |
| SCHEMBL20042685 | 0.85 | HTT (0.42) | EPHX2P2RX7HSD11B1 | |
| SCHEMBL20042817 | 0.85 | PKM (0.44) | P2RX7LMNA | |
| SCHEMBL20042765 | 0.85 | P2RX7 (0.42) | EPHX2MAPK7P2RX7MGLL | |
| SCHEMBL20042751 | 0.83 | HSD17B10 (0.49) | P2RX7MGLLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |