Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | FABP6 | P51161 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042776 | 0.88 | P2RX7 (0.41) | CFTRP2RX7MEN1KMT2AKDM4E | |
| SCHEMBL20042839 | 0.88 | P2RX7 (0.45) | CFTRHPGDP2RX7MEN1MAPT | |
| SCHEMBL20042755 | 0.86 | GRM5 (0.43) | HPGDP2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL20042873 | 0.86 | P2RX7 (0.38) | CFTRHPGDP2RX7MEN1KMT2A | |
| SCHEMBL20042674 | 0.84 | P2RX7 (0.37) | CFTRP2RX7MEN1KMT2ATDP1 | |
| SCHEMBL20042668 | 0.83 | HPGD (0.51) | HPGDP2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL20042817 | 0.83 | PKM (0.44) | HPGDP2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL20042771 | 0.82 | P2RX7 (0.47) | HPGDP2RX7MEN1MAPTKMT2A | |
| SCHEMBL20042684 | 0.82 | SMN1; SMN2 (0.52) | HPGDMAPK1P2RX7TDP1ALDH1A1 | |
| SCHEMBL20042872 | 0.81 | P2RX7 (0.44) | CFTRP2RX7SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |