Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042861 | 0.91 | P2RX7 (0.39) | P2RX7MAPK7HPGDMGLLTSHR | |
| SCHEMBL20042705 | 0.87 | EPHX2 (0.45) | P2RX7MAPK7MGLLEPHX2TRPM8 | |
| SCHEMBL20042854 | 0.82 | GRM5 (0.42) | P2RX7HPGDTSHRKDM4ECASP1 | |
| SCHEMBL20043028 | 0.81 | KDM4E (0.40) | P2RX7HPGDTSHRKDM4ECASP1 | |
| SCHEMBL20042780 | 0.81 | P2RX7 (0.43) | P2RX7MAPK7MGLLEPHX2 | |
| SCHEMBL20042694 | 0.81 | P2RX7 (0.43) | P2RX7MAPK7HPGDMGLLTSHR | |
| SCHEMBL20042765 | 0.80 | P2RX7 (0.42) | P2RX7MAPK7HPGDMGLLEPHX2 | |
| SCHEMBL20042829 | 0.80 | P2RX7 (0.41) | P2RX7HPGDTSHRKDM4ECASP1 | |
| SCHEMBL20042743 | 0.80 | P2RX7 (0.40) | P2RX7HPGDTSHRKDM4ECASP1 | |
| SCHEMBL20042873 | 0.79 | P2RX7 (0.38) | P2RX7HPGDTSHRKDM4ECASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |