Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 13/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 13/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21397761 | 0.83 | HRH3 (0.41) | OPRM1OPRL1 | |
| SCHEMBL25090277 | 0.81 | OPRM1 (0.36) | OPRM1OPRL1UBE2MDCUN1D1SIGMAR1 | |
| SCHEMBL25447572 | 0.81 | SIGMAR1 (0.46) | OPRM1OPRL1UBE2MDCUN1D1SIGMAR1 | |
| SCHEMBL19630484 | 0.79 | KDM4E (0.38) | OPRM1OPRL1UBE2MDCUN1D1 | |
| SCHEMBL11573468 | 0.79 | — | — | |
| SCHEMBL27255377 | 0.78 | — | — | |
| SCHEMBL24755103 | 0.76 | GNAI3 (0.44) | OPRM1OPRL1UBE2MDCUN1D1 | |
| SCHEMBL23733428 | 0.76 | HRH3 (0.37) | UBE2MDCUN1D1 | |
| SCHEMBL22332273 | 0.76 | CYP2D6 (0.41) | OPRM1OPRL1UBE2MDCUN1D1 | |
| SCHEMBL21150667 | 0.75 | SIGMAR1 (0.39) | OPRM1OPRL1UBE2MDCUN1D1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512852-B1 | TRAF 6 INHIBITORS | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM GESUNDHEIT & UMWELT GMBH (DE) | 2024-06-26 | — | — | EP | disclosed |
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-01-18 | — | — | US | disclosed |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | PHGDH, PGD, PGK1 | OPRM1 3425/4885OPRL1 2623/4885UBE2M 1849/4885 |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | PHGDH, PGD, PGK1 | OPRM1 3581/4885OPRL1 2904/4885UBE2M 2098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.