SCHEMBL20101786

SCHEMBL20101786

Brc1ccccc1O[SiH](c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 1/20 0.36
KDM4E B2RXH2 3/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
ALDH1A1 P00352 6/20 0.33
LMNA P02545 2/20 0.33
MAPK1 P28482 1/20 0.33
RAB9A P51151 5/20 0.33
NPC1 O15118 3/20 0.33
POLB P06746 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
GRM4 Q14833 1/20 0.32
HTR1A P08908 1/20 0.31
ADRA2A P08913 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
MAPT P10636 2/20 0.30
HPGD P15428 2/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28297290 0.74 CA1 (0.56) KMT2AALDH1A1LMNAMAPK1POLB
SCHEMBL10951654 0.73 HTR7 (0.42) HTR7MEN1KMT2AALDH1A1LMNA
SCHEMBL5051778 0.71 KIF11 (0.37)
SCHEMBL704146 0.69 ALDH1A1 (0.43) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL5696610 0.69 HTR1D (0.38) KMT2AALDH1A1SMN1; SMN2TDP1CYP1A2
SCHEMBL1930199 0.69 LTA4H (0.43) ALDH1A1RAB9ANPC1SMN1; SMN2TDP1
SCHEMBL727333 0.68 ALDH1A1 (0.48) HTR7ALDH1A1LMNAMAPK1RAB9A
SCHEMBL22131083 0.68 HTR7 (0.45) HTR7KDM4EALDH1A1LMNAMAPK1
SCHEMBL7994314 0.67 CYP1A2 (0.34) KDM4EALDH1A1TDP1CYP1A2CYP2C19
SCHEMBL3842507 0.66 MAPK1 (0.46) HTR7ALDH1A1LMNAMAPK1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180123057-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2018-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180123057-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME BMI1, PIEZO1, ETV6 HTR7 4352/4885KDM4E 1045/4885MEN1 192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.