Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20101959 | 0.81 | SIGMAR1 (0.33) | CYP19A1PDK1PDK2PDK3SIGMAR1 | |
| SCHEMBL30278681 | 0.81 | CYP19A1 (0.44) | CYP19A1PDK1PDK2PDK3SIGMAR1 | |
| SCHEMBL9382048 | 0.81 | CA12 (0.35) | CYP19A1PDK1PDK2PDK3SIGMAR1 | |
| SCHEMBL27305125 | 0.79 | PDK1 (0.47) | CYP19A1PDK1PDK2PDK3SIGMAR1 | |
| SCHEMBL9192532 | 0.79 | PDK1 (0.47) | CYP19A1PDK1PDK2PDK3SIGMAR1 | |
| SCHEMBL28629931 | 0.79 | PDK1 (0.47) | CYP19A1PDK1PDK2PDK3SIGMAR1 | |
| SCHEMBL9382425 | 0.79 | FKBP1A (0.39) | CYP19A1SIGMAR1TSHRELANECTSG | |
| SCHEMBL28549824 | 0.78 | RAB9A (0.38) | CYP19A1SIGMAR1ELANECTSGERN1 | |
| SCHEMBL9192830 | 0.76 | SIGMAR1 (0.32) | CYP19A1SIGMAR1TSHRELANECTSG | |
| SCHEMBL9192823 | 0.76 | SIGMAR1 (0.32) | CYP19A1SIGMAR1TSHRELANECTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12098151-B2 | Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative | NATIONAL UNIVERSITY COPORATION HOKKAIDO UNIVERSITY (JP) | 2024-09-24 | — | — | US | disclosed |
| US-20230287004-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2023-09-14 | — | — | US | disclosed |
| US-20230117695-A1 | ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2023-04-20 | — | — | US | disclosed |
| US-11492352-B2 | Arenavirus growth inhibitor comprising polycyclic carbamoylpyridone derivative | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2022-11-08 | — | — | US | disclosed |
| US-20210292321-A1 | ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2021-09-23 | — | — | US | disclosed |
| EP-3815689-A1 | ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | National University Corporation Hokkaido University (JP) | 2021-05-05 | — | — | EP | disclosed |
| CN-109721615-B | Inhibitors of influenza virus replication and uses thereof | 广东东阳光药业有限公司 | 2020-12-29 | — | — | CN | disclosed |
| US-20200283454-A1 | INFLUENZA VIRUS REPLICATION INHIBITOR AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-09-10 | — | — | US | disclosed |
| EP-3686201-A1 | INFLUENZA VIRUS REPLICATION INHIBITOR AND USE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-07-29 | — | — | EP | disclosed |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492352-B2 | Arenavirus growth inhibitor comprising polycyclic carbamoylpyridone derivative | LUC7L2, CXCR6, RRP12 | CYP19A1 3327/4885PDK1 3731/4885PDK2 3953/4885 |
| US-12098151-B2 | Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative | CDK7, CCNA1, CCR10 | CYP19A1 3175/4885PDK1 3229/4885PDK2 2924/4885 |
| US-20230287004-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | CYP19A1 557/4885PDK1 2249/4885PDK2 1679/4885 |
| US-20230117695-A1 | ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | CDK7, CCNA1, CCR10 | CYP19A1 3158/4885PDK1 3214/4885PDK2 2911/4885 |
| US-20210292321-A1 | ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | CCNA1, CDK7, CCR10 | CYP19A1 3027/4885PDK1 3304/4885PDK2 3109/4885 |
| US-20200283454-A1 | INFLUENZA VIRUS REPLICATION INHIBITOR AND USE THEREOF | RTF2, POLRMT, RTF1 | CYP19A1 1933/4885PDK1 2889/4885PDK2 1581/4885 |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | CYP19A1 557/4885PDK1 2249/4885PDK2 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.