Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CASP6 | P55212 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118182 | 0.87 | PDE4B (0.39) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL20118399 | 0.85 | P2RX7 (0.39) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL20118039 | 0.84 | KMT2A (0.46) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL20118185 | 0.71 | OPRM1 (0.35) | KMT2ACASP6MEN1GAAP2RX7 | |
| SCHEMBL20103445 | 0.71 | P2RX7 (0.52) | KMT2ACASP6MEN1GAAP2RX7 | |
| SCHEMBL20118237 | 0.68 | MEN1 (0.41) | KMT2ACASP6MEN1GAAP2RX7 | |
| SCHEMBL20118397 | 0.68 | P2RX7 (0.35) | KMT2ACASP6MEN1GAAP2RX7 | |
| SCHEMBL20118049 | 0.67 | CASP6 (0.36) | KMT2ACASP6MEN1GAAP2RX7 | |
| SCHEMBL20118169 | 0.64 | P2RX7 (0.35) | P2RX7 | |
| SCHEMBL16759677 | 0.63 | ALDH1A1 (0.65) | KMT2AMEN1P2RX7ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078009-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |