Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 9/20 | 0.82 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.82 |
| ▸ | CNR2 | P34972 | 5/20 | 0.82 |
| ▸ | CNR1 | P21554 | 4/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | GAA | P10253 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | PPARG | P37231 | 2/20 | 0.82 |
| ▸ | PPARD | Q03181 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.82 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.82 |
| ▸ | HPGD | P15428 | 1/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.82 |
| ▸ | TNKS | O95271 | 1/20 | 0.68 |
| ▸ | PARP1 | P09874 | 1/20 | 0.68 |
| ▸ | XDH | P47989 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Magnolol SCHEMBL23119980 | 0.91 | GABRA1 (0.85) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| Magnolol SCHEMBL29538482 | 0.91 | GABRA1 (1.00) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| Magnolol SCHEMBL132477 | 0.91 | GABRA1 (1.00) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| Magnolol SCHEMBL29649179 | 0.91 | GABRA1 (1.00) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| SCHEMBL22215973 | 0.88 | GABRA1 (0.89) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| SCHEMBL10454553 | 0.87 | GABRA1 (0.62) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| SCHEMBL7747447 | 0.86 | GABRA1 (0.77) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| SCHEMBL29763176 | 0.84 | TRPA1 (0.70) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| SCHEMBL8047684 | 0.84 | TRPA1 (0.70) | GABRA1GABRB2CNR2CNR1ALDH1A1 | |
| SCHEMBL14368297 | 0.84 | GABRA1 (0.79) | GABRA1GABRB2CNR2CNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212509-A1 | METHOD FOR PREPARING WATER-SOLUBLE MAGNOLOL DERIVATIVE AND HONOKIOL DERIVATIVE, METHODS FOR PREPARING INTERMEDIATES OF WATER-SOLUBLE MAGNOLOL DERIVATIVE AND HONOKIOL DERIVATIVE, AND RELATED MONOHYDROXY PROTECTED INTERMEDIATE | Beijing Honghui Meditech Co., Ltd (CN) | 2023-07-19 | — | — | EP | disclosed |
| US-20220211727-A1 | Mito-Magnolol Compounds and Methods of Synthesis and Use Thereof | AIX-MARSEILLE UNIVERSITE (FR) | 2022-07-07 | — | — | US | disclosed |
| US-11083739-B2 | Mito-magnolol compounds and methods of synthesis and use thereof | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| US-10836782-B2 | Mito-honokiol compounds and methods of synthesis and use thereof | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2020-11-17 | — | — | US | disclosed |
| US-20200222433-A1 | MITO-MAGNOLOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF | THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) | 2020-07-16 | — | — | US | disclosed |
| US-20180134737-A1 | MITO-HONOKIOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF | THE MEDICAL COLLEGE OF WISCONSIN, INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220211727-A1 | Mito-Magnolol Compounds and Methods of Synthesis and Use Thereof | CYP11B1, MFN2, CYP11B2 | GABRA1 2692/4885GABRB2 1803/4885CNR2 2796/4885 |
| US-20180134737-A1 | MITO-HONOKIOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF | MFN2, MT-ND2, PCK2 | GABRA1 4171/4885GABRB2 3927/4885CNR2 2830/4885 |
| US-20200222433-A1 | MITO-MAGNOLOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF | CYP11B1, MFN2, CYP11B2 | GABRA1 2692/4885GABRB2 1803/4885CNR2 2796/4885 |
| US-11083739-B2 | Mito-magnolol compounds and methods of synthesis and use thereof | CYP11B1, MFN2, CYP11B2 | GABRA1 2692/4885GABRB2 1803/4885CNR2 2796/4885 |
| US-10836782-B2 | Mito-honokiol compounds and methods of synthesis and use thereof | MFN2, MT-ND2, PCK2 | GABRA1 4171/4885GABRB2 3927/4885CNR2 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.