Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407969 | 0.85 | GAA (0.36) | HPGDALDH1A1GAAHSD17B10USP2 | |
| SCHEMBL22303989 | 0.85 | ALDH1A1 (0.41) | HPGDALDH1A1GAAHSD17B10USP2 | |
| SCHEMBL249358 | 0.80 | ALDH1A1 (0.43) | HPGDALDH1A1GAAHSD17B10USP2 | |
| SCHEMBL18713788 | 0.80 | TSHR (0.41) | HPGDALDH1A1ALOX15TSHRRORC | |
| SCHEMBL5377888 | 0.80 | ALDH1A1 (0.47) | HPGDALDH1A1GAAHSD17B10USP2 | |
| SCHEMBL283021 | 0.79 | GABRA1 (0.46) | ALDH1A1GAAALOX15TSHRKDM4E | |
| SCHEMBL1861859 | 0.78 | RORC (0.58) | HPGDALDH1A1GAAHSD17B10USP2 | |
| SCHEMBL11417210 | 0.78 | ALOX15 (0.46) | HPGDALDH1A1GAAHSD17B10USP2 | |
| SCHEMBL11514222 | 0.78 | ALDH1A1 (0.59) | HPGDALDH1A1GAAHSD17B10USP2 | |
| SCHEMBL2015924 | 0.78 | KDM4E (0.39) | ALDH1A1GAAALOX15TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130217783-A1 | Therapeutic Compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-8350097-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120196939-A1 | Therapeutic Compounds | SOWOOD HEALTHCARE LLC | 2012-08-02 | — | — | US | disclosed |
| US-8173849-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| EP-2152651-B1 | THERAPEUTIC COMPOUNDS | PHARMACOFORE INC (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2392559-A1 | Therapeutic compounds | Pharmacofore, Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| US-20100249246-A1 | Therapeutic Compounds | PHARMACOFORE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| CN-101687746-A | therapeutic compounds | PHARMACOFORE INC | 2010-03-31 | — | — | CN | disclosed |
| EP-2152651-A1 | THERAPEUTIC COMPOUNDS | Pharmacofore, Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008141099-A1 | THERAPEUTIC COMPOUNDS | PHARMACOFORE, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
| US-4925984-A | REACTION WITH BROMINE IN SOLUTION | ETHYL CORPORATION (US) | 1990-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217783-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | HPGD 365/4885ALDH1A1 112/4885GAA 750/4885 |
| US-20100249246-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | HPGD 365/4885ALDH1A1 112/4885GAA 750/4885 |
| US-20120196939-A1 | Therapeutic Compounds | OPRM1, OPRD1, SCN1B | HPGD 566/4885ALDH1A1 257/4885GAA 1721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.