Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Glycoursodeoxycholic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 known ✓ | Q12908 | 4/20 | 0.71 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.70 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.70 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.70 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.70 |
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.82 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 5/20 | 0.82 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.82 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.71 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.70 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycoursodeoxycholic Acid SCHEMBL7206212 | 0.99 | GPBAR1 (0.83) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| Glycoursodeoxycholic Acid SCHEMBL29366725 | 0.99 | GPBAR1 (0.83) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| Glycoursodeoxycholic Acid SCHEMBL61042 | 0.99 | GPBAR1 (0.83) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| Glycoursodeoxycholic Acid SCHEMBL178105 | 0.97 | GPBAR1 (0.83) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| Glycoursodeoxycholic Acid SCHEMBL935341 | 0.90 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| Glycoursodeoxycholic Acid SCHEMBL9151495 | 0.90 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| Glycoursodeoxycholic Acid SCHEMBL59881 | 0.90 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| Glycoursodeoxycholic Acid SCHEMBL12917601 | 0.90 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| Glycochenodeoxycholate SCHEMBL236354 | 0.90 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11ENPP2NR3C1 | |
| SCHEMBL19104663 | 0.90 | GPBAR1 (0.86) | GPBAR1NR1H4ABCB11ENPP2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110159087-A1 | Crosslinked Polymers | USV LIMITED (IN) | 2011-06-30 | — | — | US | claimed |
| WO-2010041268-A2 | CROSSLINKED POLYMERS | USV LIMITED (IN) | 2010-04-15 | — | — | WO | claimed |
| US-20110159087-A1 | Crosslinked Polymers | USV LIMITED (IN) | 2011-06-30 | — | — | US | disclosed |
| WO-2010041268-A2 | CROSSLINKED POLYMERS | USV LIMITED (IN) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110159087-A1 | Crosslinked Polymers | SLC10A1, CETP, SLC10A2 | SLC10A2 3/4885MEN1 3759/4885CHRM2 2878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.