Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | NEK4 | P51957 | 2/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.38 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217347 | 0.78 | ALDH1A1 (0.47) | TAS1R3TAS1R1PPARGKDM4EGAA | |
| SCHEMBL20217243 | 0.77 | KDM4E (0.51) | PPARGKDM4EALDH1A1 | |
| SCHEMBL29142735 | 0.77 | KDM4E (0.54) | KDM4EGAAROCK1ROCK2RPS6KA5 | |
| SCHEMBL20217342 | 0.76 | APLNR (0.49) | PPARG | |
| SCHEMBL20217138 | 0.76 | ROCK1 (0.52) | TAS1R3TAS1R1KDM4EGAAROCK1 | |
| SCHEMBL20217468 | 0.75 | KMT2A (0.41) | KDM4EGAAMAPK1ALDH1A1 | |
| SCHEMBL20217203 | 0.75 | TAS1R3 (0.59) | TAS1R3TAS1R1ROCK1ROCK2MAPK1 | |
| SCHEMBL20217161 | 0.74 | MEN1 (0.52) | AKT1CDK2MAPK1ALDH1A1 | |
| SCHEMBL20217534 | 0.72 | ROCK1 (0.48) | TAS1R3TAS1R1PPARGROCK1ROCK2 | |
| SCHEMBL29142739 | 0.71 | UTS2R (0.48) | KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |