Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 5/20 | 0.40 |
| ▸ | F2 | P00734 | 4/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | F7 | P08709 | 4/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217833 | 0.76 | HRH1 (0.42) | KMT2AMEN1F3F2F10 | |
| SCHEMBL20217251 | 0.76 | ACSS2 (0.38) | F3F2F10F7PRSS1 | |
| SCHEMBL20217634 | 0.75 | TAS1R3 (0.40) | KDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL20217243 | 0.71 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL20217161 | 0.70 | MEN1 (0.52) | KMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL16292558 | 0.70 | MAPK1 (0.45) | KMT2AMEN1KDM4EALDH1A1TP53 | |
| SCHEMBL20217344 | 0.68 | ALDH1A1 (0.53) | KDM4EALDH1A1RAB9AHDAC8HDAC6 | |
| SCHEMBL3782099 | 0.68 | MTNR1A (0.71) | KMT2AMEN1NPC1RAB9AHDAC8 | |
| SCHEMBL20217342 | 0.67 | APLNR (0.49) | — | |
| SCHEMBL18572792 | 0.67 | ALDH1A1 (0.58) | KMT2AMEN1KDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |