Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | CCR6 | P51684 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24877524 | 0.84 | KCNH2 (0.45) | KCNH2CCR6NOTUMCARM1PRMT6 | |
| SCHEMBL12876072 | 0.77 | TAS1R3 (0.44) | NOTUMKDM1ACARM1PRMT6CYP2D6 | |
| SCHEMBL23993603 | 0.77 | TAS1R3 (0.44) | NOTUMKDM1ACARM1PRMT6CYP2D6 | |
| SCHEMBL14011291 | 0.76 | MEN1 (0.51) | KCNH2KDM1ACYP2D6SLC6A2SLC6A4 | |
| SCHEMBL14011287 | 0.76 | MEN1 (0.51) | KCNH2KDM1ACYP2D6SLC6A2SLC6A4 | |
| SCHEMBL18656539 | 0.75 | MAP4K1 (0.51) | NOTUM | |
| SCHEMBL30228465 | 0.75 | MAP4K1 (0.51) | NOTUM | |
| SCHEMBL15743961 | 0.73 | HSD17B2 (0.43) | KCNH2NOTUMFFAR1 | |
| SCHEMBL25004988 | 0.72 | ALOX5 (0.45) | KCNH2KDM1ASLC6A4FFAR1 | |
| SCHEMBL8974437 | 0.72 | KIF11 (0.41) | NOTUMKDM1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954215-B2 | Compounds as modulators of ROR gamma | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-03-23 | — | — | US | disclosed |
| EP-3555065-B1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2021-02-24 | — | — | EP | disclosed |
| US-20200071298-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-03-05 | — | — | US | disclosed |
| WO-2018111803-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10954215-B2 | Compounds as modulators of ROR gamma | RORB, RORC, RORA | KCNH2 4425/4885CCR6 276/4885NOTUM 3670/4885 |
| US-20200071298-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | RORC, RORB, RORA | KCNH2 4351/4885CCR6 248/4885NOTUM 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.