Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 6/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6267261 | 0.86 | SMN1; SMN2 (0.62) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL9306708 | 0.85 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL9734141 | 0.81 | THRB (0.56) | NPC1RAB9ASMN1; SMN2TDP1HDAC6 | |
| SCHEMBL9305296 | 0.81 | PIK3CA (0.50) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL25252536 | 0.81 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL30063475 | 0.81 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL1105986 | 0.81 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL9307022 | 0.79 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL11147962 | 0.79 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL9307890 | 0.79 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126229-A | No background contamination | FUJI PHOTO FILM CO., LTD. (JP) | 1992-06-30 | — | — | US | claimed |
| US-4021248-A | SILVER HALIDE | FUJI PHOTO FILM CO., LTD. (JA) | 1977-05-03 | — | — | US | claimed |
| JP-4170538-A | — | — | None | — | — | JP | disclosed |
| CN-121471212-A | High-temperature high-acid stable heavy metal chelating agent and preparation method and application thereof | 成都汇锦水务发展有限公司 | 2026-02-06 | — | — | CN | disclosed |
| US-20240132705-A1 | RUBBER COMPOSITION AND CROSSLINKED RUBBER MOLDED PRODUCT | SUMITOMO RUBBER INDUSTRIES, LTD. (JP) | 2024-04-25 | — | — | US | disclosed |
| CN-107743483-B | NADPH oxidase 4 inhibitors | 埃科特莱茵药品有限公司 | 2022-01-28 | — | — | CN | disclosed |
| US-20210395238-A1 | NADPH OXIDASE 4 INHIBITORS | ACTELTION PHARMACEUTICALS LTD (CH) | 2021-12-23 | — | — | US | disclosed |
| US-11136317-B2 | NADPH oxidase 4 inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2021-10-05 | — | — | US | disclosed |
| EP-3310767-B1 | 2,5-DISUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AS NADPH OXIDASE 4 INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2020-07-22 | — | — | EP | disclosed |
| US-20200165235-A1 | NADPH OXIDASE 4 INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2020-05-28 | — | — | US | disclosed |
| US-10584118-B2 | NADPH oxidase 4 inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2020-03-10 | — | — | US | disclosed |
| EP-0161220-A2 | Process for the preparation of beta-(benzothiazolylthio) and beta (benzimidazolylthio)carboxylic-acid derivatives | CIBA-GEIGY AG (CH) | 1985-11-13 | — | — | EP | disclosed |
| EP-0137426-A2 | 2-Mercaptothiazole derivatives, process for their preparation and utilization of 2-mercaptothiazole derivatives in pharmaceutical compounds | BAYER AG (DE) | 1985-04-17 | — | — | EP | disclosed |
| EP-0129506-A2 | Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids | CIBA-GEIGY AG (CH) | 1984-12-27 | — | — | EP | disclosed |
| EP-0126030-A2 | Process for the preparation of beta-(benzothiazolylthio) and beta-(benzimidazolylthio) carboxylic acids | CIBA-GEIGY AG (CH) | 1984-11-21 | — | — | EP | disclosed |
| US-4343660-A | PETROLEUM SULFONATE AND COMPLEXING AGENT, FOR COPPER CABLES | PETROLITE CORPORATION (US) | 1982-08-10 | — | — | US | disclosed |
| US-4322214-A | USING A SULFUR OR SULFURIZED VAT DYE IN AN ALKALINE BATH CONTAINING A MERCAPTO COMPOUND AND A SULFITE SALT; LEVELING | ASAHI CHEMICAL COMPANY LIMITED (JP) | 1982-03-30 | — | — | US | disclosed |
| US-4138346-A | ETHOXYLATED PHOSPHATE ESTER WITH A MERCAPTOTHIAZOLE, A DITHIOBIS-THIAZOLE, A SULFIDE, A DISULFIDE OR A SULFONE | BASF WYANDOTTE CORPORATION (US) | 1979-02-06 | — | — | US | disclosed |
| US-4021248-A | SILVER HALIDE | FUJI PHOTO FILM CO., LTD. (JA) | 1977-05-03 | — | — | US | disclosed |
| US-3933658-A | PHOSPHATE ESTER AND SULFUR COMPOUND | GAF CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10584118-B2 | NADPH oxidase 4 inhibitors | NOX4, NOX1, CYBB | NPC1 3120/4885RAB9A 2128/4885SMN1; SMN2 3582/4885 |
| US-20200165235-A1 | NADPH OXIDASE 4 INHIBITORS | NOX4, NOX1, CYBB | NPC1 3120/4885RAB9A 2128/4885SMN1; SMN2 3582/4885 |
| US-11136317-B2 | NADPH oxidase 4 inhibitors | NOX4, NOX1, CYBB | NPC1 3120/4885RAB9A 2128/4885SMN1; SMN2 3582/4885 |
| US-20210395238-A1 | NADPH OXIDASE 4 INHIBITORS | NOX4, NOX1, CYBB | NPC1 3120/4885RAB9A 2128/4885SMN1; SMN2 3582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.