SCHEMBL20511752

SCHEMBL20511752

COC(=O)C1Cc2cc(F)c(F)cc2C1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.47
BRD4 O60885 1/20 0.41
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CHRNB2 P17787 2/20 0.36
CHRNA4 P43681 2/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA7 P36544 1/20 0.36
F2 P00734 3/20 0.35
F10 P00742 1/20 0.35
PKM P14618 1/20 0.35
BUB1 O43683 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30862624 1.00 KMT2A (0.47) KMT2ABRD4KDM4EALDH1A1CHRNB2
SCHEMBL21557465 0.88 KMT2A (0.42) KMT2ABRD4KDM4EALDH1A1F2
SCHEMBL1340597 0.82 KMT2A (0.47) KMT2ABRD4ALDH1A1
SCHEMBL29443104 0.82 KMT2A (0.47) KMT2ABRD4ALDH1A1
SCHEMBL19669833 0.81 ALDH1A1 (0.54) KMT2AKDM4EALDH1A1
SCHEMBL29992013 0.81 KMT2A (0.47) KMT2ABRD4KDM4EALDH1A1PKM
SCHEMBL346652 0.80 DRD2 (0.39) KMT2AKDM4EALDH1A1
SCHEMBL345477 0.78 KMT2A (0.41) KMT2AKDM4EALDH1A1
SCHEMBL5889366 0.78 KMT2A (0.41) KMT2AKDM4EALDH1A1
SCHEMBL8071191 0.78 KMT2A (0.41) KMT2AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12286411-B2 Indane derivatives for use in the treatment of bacterial infection ANTABIO SAS (FR) 2025-04-29 US disclosed
US-12247013-B2 Indane derivatives for use in the treatment of bacterial infection ANTABIO SAS (FR) 2025-03-11 US disclosed
CN-113166084-B Indane derivatives for the treatment of bacterial infections 安塔比奥公司 2024-06-04 CN disclosed
CN-113166085-B Indane derivatives for the treatment of bacterial infections 安塔比奥公司 2024-04-09 CN disclosed
US-20240016941-A1 COMBINATION THERAPY ANTABIO SAS (FR) 2024-01-18 US disclosed
US-20240016941-A1 COMBINATION THERAPY ANTABIO SAS (FR) 2024-01-18 US disclosed
US-20240016941-A1 COMBINATION THERAPY ANTABIO SAS (FR) 2024-01-18 US disclosed
EP-3601224-B1 CHEMICAL COMPOUNDS AS ANTIBIOTICS ANTABIO SAS (FR) 2023-07-05 EP disclosed
CN-110914238-B Compounds as antibiotics 安塔比奥公司 2023-06-20 CN disclosed
US-20220112169-A1 INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION ANTABIO SAS (FR) 2022-04-14 US disclosed
CN-113166085-A Indane derivatives for the treatment of bacterial infections 安塔比奥公司 2021-07-23 CN disclosed
CN-113166084-A Indane derivatives for the treatment of bacterial infections 安塔比奥公司 2021-07-23 CN disclosed
US-11000511-B2 Chemical compounds as antibiotics ANTABIO SAS (FR) 2021-05-11 US disclosed
US-20200155509-A1 CHEMICAL COMPOUNDS AS ANTIBIOTICS ANTABIO SAS (FR) 2020-05-21 US disclosed
EP-3628666-A1 INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION Antabio SAS (FR) 2020-04-01 EP disclosed
EP-3628672-A1 INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION Antabio SAS (FR) 2020-04-01 EP disclosed
EP-3628672-A1 INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION Antabio SAS (FR) 2020-04-01 EP disclosed
CN-110914238-A Compounds as antibiotics 安塔比奥公司 2020-03-24 CN disclosed
EP-3601224-A1 CHEMICAL COMPOUNDS AS ANTIBIOTICS Antabio SAS (FR) 2020-02-05 EP disclosed
WO-2018172423-A1 CHEMICAL COMPOUNDS AS ANTIBIOTICS ANTABIO SAS (FR) 2018-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220112169-A1 INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION ARG1, ELANE, INSR KMT2A 3582/4885BRD4 1007/4885KDM4E 3775/4885
US-12286411-B2 Indane derivatives for use in the treatment of bacterial infection ELANE, ARG1, INSRR KMT2A 3671/4885BRD4 1018/4885KDM4E 3917/4885
US-20200155509-A1 CHEMICAL COMPOUNDS AS ANTIBIOTICS MRPL21, CFTR, H1-0 KMT2A 825/4885BRD4 1863/4885KDM4E 2060/4885
US-20240016941-A1 COMBINATION THERAPY CFTR, ABCB11, SLC26A4 KMT2A 2615/4885BRD4 1651/4885KDM4E 4573/4885
US-11000511-B2 Chemical compounds as antibiotics MRPL21, CFTR, H1-0 KMT2A 825/4885BRD4 1863/4885KDM4E 2060/4885
US-12247013-B2 Indane derivatives for use in the treatment of bacterial infection ELANE, ARG1, INSRR KMT2A 3671/4885BRD4 1018/4885KDM4E 3917/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.