SCHEMBL20522637

SCHEMBL20522637

Cn1nc(Cl)c(O)c(-c2c3ccccc3cc3ccccc23)c1=O

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ NPEPPS P55786 1/20 0.37
▸ NQO1 P15559 1/20 0.36
▸ ALOX5 P09917 1/20 0.36
▸ KMT2A Q03164 4/20 0.35
▸ HPGD P15428 3/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ DAO P14920 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ PKM P14618 1/20 0.35
▸ CASP1 P29466 1/20 0.35
▸ GALK1 P51570 1/20 0.35
▸ BLM P54132 1/20 0.35
▸ CASP7 P55210 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ SAE1 Q9UBE0 1/20 0.35
▸ UBA2 Q9UBT2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20522635 0.86 SMN1; SMN2 (0.36) KMT2AHPGDSMN1; SMN2MEN1NPSR1
SCHEMBL29761334 0.86 SMN1; SMN2 (0.36) KMT2AHPGDSMN1; SMN2MEN1NPSR1
SCHEMBL25202984 0.85 HPGD (0.38) KMT2AHPGDSMN1; SMN2MEN1GAA
SCHEMBL29058918 0.84 MEN1 (0.34) NQO1KMT2AHPGDSMN1; SMN2MEN1
SCHEMBL20522634 0.83 SMN1; SMN2 (0.35) KMT2AHPGDSMN1; SMN2MEN1LMNA
SCHEMBL20522633 0.81 ALDH1A1 (0.41) ALOX5HPGDSMN1; SMN2NPSR1LMNA
SCHEMBL28627221 0.80 HPGD (0.39) KMT2AHPGDSMN1; SMN2MEN1NPSR1
SCHEMBL18797102 0.79 COMT (0.36) KMT2AHPGDSMN1; SMN2NPSR1LMNA
SCHEMBL29058636 0.76 SMN1; SMN2 (0.37) KMT2AHPGDSMN1; SMN2MEN1NPSR1
Morpholine SCHEMBL28609463 0.75 ATM (0.36) KMT2AHPGDSMN1; SMN2MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11292770-B2 Pyridazinone herbicides FMC CORPORATION (US) 2022-04-05 — — US claimed
EP-3601263-B1 NOVEL PYRIDAZINONE HERBICIDES FMC CORP (US) 2021-10-13 — — EP claimed
US-20200109123-A1 NOVEL PYRIDAZINONE HERBICIDES FMC CORPORATION 2020-04-09 — — US claimed
EP-3601263-A1 NOVEL PYRIDAZINONE HERBICIDES FMC Corporation (US) 2020-02-05 — — EP claimed
WO-2018183432-A1 NOVEL PYRIDAZINONE HERBICIDES FMC CORPORATION (US) 2018-10-04 — — WO claimed
EP-4267556-B1 SUBSTITUTED PYRIDAZINONE HERBICIDES FMC CORP (US) 2025-04-09 — — EP disclosed
US-20240101519-A1 SUBSTITUTED PYRIDAZINONE HERBICIDES FMC CORPORATION 2024-03-28 — — US disclosed
EP-4267556-A1 SUBSTITUTED PYRIDAZINONE HERBICIDES FMC CORPORATION (US) 2023-11-01 — — EP disclosed
CN-116635386-A Substituted pyridazinone herbicides FMC公司 2023-08-22 — — CN disclosed
WO-2022140309-A1 SUBSTITUTED PYRIDAZINONE HERBICIDES FMC CORPORTION (US) 2022-06-30 — — WO disclosed
US-11292770-B2 Pyridazinone herbicides FMC CORPORATION (US) 2022-04-05 — — US disclosed
EP-3601263-B1 NOVEL PYRIDAZINONE HERBICIDES FMC CORP (US) 2021-10-13 — — EP disclosed
US-20200109123-A1 NOVEL PYRIDAZINONE HERBICIDES FMC CORPORATION 2020-04-09 — — US disclosed
EP-3601263-A1 NOVEL PYRIDAZINONE HERBICIDES FMC Corporation (US) 2020-02-05 — — EP disclosed
CN-110741000-A Novel pyridazinone herbicides FMC公司 2020-01-31 — — CN disclosed
WO-2018183432-A1 NOVEL PYRIDAZINONE HERBICIDES FMC CORPORATION (US) 2018-10-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240101519-A1 SUBSTITUTED PYRIDAZINONE HERBICIDES PRDX4, PRDX6, PDXK NPEPPS 3410/4885NQO1 193/4885ALOX5 1850/4885
US-11292770-B2 Pyridazinone herbicides PRDX6, PRDX4, PDXK NPEPPS 3984/4885NQO1 263/4885ALOX5 623/4885
US-20200109123-A1 NOVEL PYRIDAZINONE HERBICIDES PRDX6, PRDX4, CHRM2 NPEPPS 4066/4885NQO1 354/4885ALOX5 921/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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