Morpholine

Morpholine

SCHEMBL28609463

C1COCCN1.Cc1ccc2ccccc2c1-c1c(O)c(Cl)nn(C)c1=O

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ HPGD P15428 4/20 0.35
▸ MAPK1 P28482 3/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ HTT P42858 1/20 0.35
▸ KMT2A Q03164 3/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ GAA P10253 2/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ SSTR4 P31391 4/20 0.32
▸ HSD17B10 Q99714 1/20 0.31
▸ SSTR1 P30872 1/20 0.31
▸ SSTR2 P30874 1/20 0.31
▸ SSTR3 P32745 1/20 0.31
▸ SSTR5 P35346 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25202984 0.88 HPGD (0.38) L3MBTL1HPGDSMN1; SMN2KMT2AMEN1
SCHEMBL21835458 0.77 HSD11B1 (0.38) HPGDSMN1; SMN2KMT2AMEN1ALDH1A1
SCHEMBL29383185 0.77 HSD11B1 (0.38) HPGDSMN1; SMN2KMT2AMEN1ALDH1A1
SCHEMBL29443524 0.76 MEN1 (0.33) HPGDMAPK1SMN1; SMN2HTTKMT2A
SCHEMBL21835397 0.76 MEN1 (0.33) HPGDMAPK1SMN1; SMN2HTTKMT2A
SCHEMBL25184883 0.76 MAPK8 (0.37) L3MBTL1HTTKMT2AMEN1KDM4E
SCHEMBL20522637 0.75 NPEPPS (0.37) HPGDSMN1; SMN2KMT2AMEN1GAA
SCHEMBL30834467 0.74 TSHR (0.38) L3MBTL1SMN1; SMN2HTTKMT2AKDM4E
SCHEMBL21835495 0.73 NPBWR1 (0.41) HPGDSMN1; SMN2KMT2AMEN1ALDH1A1
SCHEMBL29382816 0.73 NPBWR1 (0.41) HPGDSMN1; SMN2KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12435044-B2 Pyridazinone herbicides and pyridazinone intermediates used to prepare a herbicide FMC CORPORATION (US) 2025-10-07 — — US disclosed
CN-119039233-A Pyridazinone herbicides and pyridazinone intermediates for preparing the same FMC公司 2024-11-29 — — CN disclosed
CN-118994028-A Pyridazinone herbicides and pyridazinone intermediates for preparing the same FMC公司 2024-11-22 — — CN disclosed
CN-113166075-B Pyridazinone herbicides and pyridazinone intermediates for preparing the same FMC公司 2024-10-25 — — CN disclosed
US-20220041560-A1 PYRIDAZINONE HERBICIDES AND PYRIDAZINONE INTERMEDIATES USED TO PREPARE A HERBICIDE FMC CORPORATION 2022-02-10 — — US disclosed
CN-113166075-A Pyridazinone herbicides and pyridazinone intermediates for the preparation thereof FMC公司 2021-07-23 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12435044-B2 Pyridazinone herbicides and pyridazinone intermediates used to prepare a herbicide CBR3, CBR1, CYP4F3 ATM 2682/4885L3MBTL1 2126/4885HPGD 477/4885
US-20220041560-A1 PYRIDAZINONE HERBICIDES AND PYRIDAZINONE INTERMEDIATES USED TO PREPARE A HERBICIDE CBR3, CBR1, CYP4F3 ATM 2682/4885L3MBTL1 2126/4885HPGD 477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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