Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.46 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.46 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.46 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SHBG | P04278 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19697074 | 0.98 | PTGS2 (0.47) | PTGS2ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL28176546 | 0.98 | PTGS2 (0.47) | PTGS2ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL28162889 | 0.98 | PTGS2 (0.47) | PTGS2ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL3192861 | 0.98 | PTGS2 (0.47) | PTGS2ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL13211848 | 0.90 | HSD11B1 (0.40) | PTGS2ESR1ADRA2AADORA3TACR2 | |
| Hydrochloric Acid SCHEMBL30330881 | 0.88 | HSD11B1 (0.39) | PTGS2ESR1ADRA2AADORA3TACR2 | |
| Cyanide SCHEMBL30330747 | 0.85 | HSD11B1 (0.37) | PTGS2ESR1ADRA2AADORA3TACR2 | |
| Fluoride SCHEMBL30330951 | 0.81 | LPL (0.35) | LPLLIPGMGLL | |
| Acetic Acid SCHEMBL30212982 | 0.80 | ALDH1A1 (0.47) | KDM4ELMNAALDH1A1CYP3A4HIF1A | |
| SCHEMBL30330737 | 0.79 | CA2 (0.41) | KDM4EALDH1A1HSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10119065-B2 | Composition for fracturing and displacement and method for fracturing and displacement of tight oil reservoir | CHINA UNIVERSITY OF GEOSCIENCES (BEIJING) (CN) | 2018-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10119065-B2 | Composition for fracturing and displacement and method for fracturing and displacement of tight oil reservoir | ELOVL3, ELOVL1, ABHD6 | ADRA2A 4053/4885SLC6A2 4429/4885SLC6A4 4749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.