Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691733 | 0.89 | ALDH1A1 (0.56) | ALDH1A1PKMCA12CA2CA9 | |
| SCHEMBL4608472 | 0.85 | PKM (0.46) | ALDH1A1PKMCA12CA2CA9 | |
| SCHEMBL4207227 | 0.85 | CA2 (0.49) | ALDH1A1PKMCA12CA2CA9 | |
| Hydrochloric Acid SCHEMBL4609743 | 0.84 | PKM (0.45) | ALDH1A1PKMCA12CA2CA9 | |
| SCHEMBL8187498 | 0.81 | TRPV4 (0.51) | ALDH1A1PKMNPSR1MEN1CYP1A2 | |
| SCHEMBL1939161 | 0.77 | PDIA6 (0.42) | ALDH1A1PKMCA12CA2CA9 | |
| SCHEMBL28301192 | 0.76 | MAPT (0.50) | PKMCA12CA2CA9CA1 | |
| SCHEMBL11153056 | 0.76 | CA2 (0.50) | ALDH1A1PKMCA12CA2CA9 | |
| SCHEMBL791503 | 0.76 | CA2 (0.50) | PKMCA12CA2CA9CA1 | |
| SCHEMBL4609865 | 0.74 | PKM (0.43) | ALDH1A1PKMCA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273241-B2 | Cortistatin analogues and syntheses and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180319814-A1 | CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319814-A1 | CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF | CDK19, CDK9, CDK1 | ALDH1A1 3546/4885PKM 1488/4885CA12 1766/4885 |
| US-10273241-B2 | Cortistatin analogues and syntheses and uses thereof | CDK19, CDK9, CDK1 | ALDH1A1 3546/4885PKM 1488/4885CA12 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.