Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23098492 | 0.85 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1KDM4EGAASORT1 | |
| SCHEMBL27088050 | 0.76 | NPC1 (0.42) | SMN1; SMN2ALDH1A1KDM4EGAAL3MBTL1 | |
| SCHEMBL4380509 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1KDM4EGAARAB9A | |
| SCHEMBL7849700 | 0.75 | LMNA (0.51) | ALDH1A1KDM4EGAAL3MBTL1KMT2A | |
| SCHEMBL17007137 | 0.75 | HCRTR1 (0.63) | HCRTR1 | |
| SCHEMBL1499037 | 0.74 | GLA (0.49) | SMN1; SMN2ALDH1A1KDM4EAGBL2GAA | |
| SCHEMBL22583216 | 0.72 | GPR35 (0.47) | SMN1; SMN2ALDH1A1KDM4EAGBL2GAA | |
| SCHEMBL9952941 | 0.72 | AGBL2 (0.45) | SMN1; SMN2ALDH1A1KDM4EAGBL2GAA | |
| SCHEMBL17315809 | 0.71 | AGBL2 (0.44) | SMN1; SMN2ALDH1A1KDM4EAGBL2GAA | |
| SCHEMBL1498826 | 0.70 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1KDM4EAGBL2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124494-B2 | Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-09-21 | — | — | US | disclosed |
| EP-3634956-B1 | ARYL HETEROCYCLIC PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2021-04-07 | — | — | EP | disclosed |
| US-20210078971-A1 | ARYL HETEROCYCLIC PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2021-03-18 | — | — | US | disclosed |
| EP-3634956-A1 | ARYL HETEROCYCLIC PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS | Bristol-Myers Squibb Company (US) | 2020-04-15 | — | — | EP | disclosed |
| WO-2018227061-A1 | ARYL HETEROCYCLIC PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124494-B2 | Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists | FPR1, FPR2, FPR3 | SMN1; SMN2 4391/4885ALDH1A1 3593/4885KDM4E 4563/4885 |
| US-20210078971-A1 | ARYL HETEROCYCLIC PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS | FPR1, FPR2, FPR3 | SMN1; SMN2 4391/4885ALDH1A1 3593/4885KDM4E 4563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.