Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2058978 | 1.00 | ALDH1A1 (0.46) | ALDH1A1USP2GAAKDM4EMAPT | |
| SCHEMBL2058977 | 1.00 | ALDH1A1 (0.46) | ALDH1A1USP2GAAKDM4EMAPT | |
| SCHEMBL26118933 | 1.00 | ALDH1A1 (0.46) | ALDH1A1USP2GAAKDM4EMAPT | |
| SCHEMBL12589591 | 0.84 | ALDH1A1 (0.32) | ALDH1A1USP2GAAKDM4EMAPT | |
| SCHEMBL19293546 | 0.82 | ALDH1A1 (0.45) | ALDH1A1USP2GAAKDM4EMAPT | |
| SCHEMBL2058680 | 0.81 | CYP2D6 (0.37) | ALDH1A1USP2GAAKDM4EMAPT | |
| SCHEMBL2058966 | 0.81 | CYP2D6 (0.37) | ALDH1A1USP2GAAKDM4EMAPT | |
| SCHEMBL2058429 | 0.79 | KMT2A (0.38) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL2058970 | 0.79 | KMT2A (0.38) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL24088541 | 0.78 | ALDH1A1 (0.45) | ALDH1A1USP2GAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968605-B2 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. (PT) | 2011-06-28 | — | — | US | disclosed |
| US-7968605-B2 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. (PT) | 2011-06-28 | — | — | US | disclosed |
| US-7968605-B2 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. (PT) | 2011-06-28 | — | — | US | disclosed |
| EP-2099439-A2 | METHODS FOR TREATING INFLAMMATORY DISEASE BY ADMINISTERING ALDEHYDES AND DERIVATIVES THEREOF | ALFAMA - INVESTIGAÇÃO E DESENVOLVIMENTO DE PRODUTO (PT) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008069688-A2 | METHODS FOR TREATING INFLAMMATORY DISEASE BY ADMINISTERING ALDEHYDES AND DERIVATIVES THEREOF | ALFAMA - INVESTIGAÇÃO E DESENVOLVIMENTO DE PRODUTOS FARMACÊUTICOS LDA (PT) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008069688-A2 | METHODS FOR TREATING INFLAMMATORY DISEASE BY ADMINISTERING ALDEHYDES AND DERIVATIVES THEREOF | ALFAMA - INVESTIGAÇÃO E DESENVOLVIMENTO DE PRODUTOS FARMACÊUTICOS LDA (PT) | 2008-06-12 | — | — | WO | disclosed |
| US-20080026984-A1 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA - INVESTIGACAO E DESENVOLVIMENTO DE PRODUCTOS FARMACEUTICOS LDA (PT) | 2008-01-31 | — | — | US | disclosed |
| US-20080026984-A1 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA - INVESTIGACAO E DESENVOLVIMENTO DE PRODUCTOS FARMACEUTICOS LDA (PT) | 2008-01-31 | — | — | US | disclosed |
| US-20080026984-A1 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA - INVESTIGACAO E DESENVOLVIMENTO DE PRODUCTOS FARMACEUTICOS LDA (PT) | 2008-01-31 | — | — | US | disclosed |
| US-20070219120-A1 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA - INVESTIGACAO E DESENVOLVIMENTO DE PRODUCTOS FARMACEUTICOS LDA (PT) | 2007-09-20 | — | — | US | disclosed |
| US-20070219120-A1 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA - INVESTIGACAO E DESENVOLVIMENTO DE PRODUCTOS FARMACEUTICOS LDA (PT) | 2007-09-20 | — | — | US | disclosed |
| US-20070219120-A1 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | ALFAMA - INVESTIGACAO E DESENVOLVIMENTO DE PRODUCTOS FARMACEUTICOS LDA (PT) | 2007-09-20 | — | — | US | disclosed |
| US-20070112216-A1 | Method for producing chiral mercapto amino acids | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2007-05-17 | — | — | US | disclosed |
| US-6894170-B2 | Process for the preparation of substituted thiazolines and their intermediates | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2005-05-17 | — | — | US | disclosed |
| US-20050101782-A1 | Process for the preparation of substituted thiazolines and their intermediates | KRICH SYLVIA (AT) | 2005-05-12 | — | — | US | disclosed |
| US-20030186958-A1 | Heterocyclic metalloprotease inhibitors | THE PROCTER & GAMBLE COMPANY | 2003-10-02 | — | — | US | disclosed |
| US-20030088105-A1 | Process for the preparation of substituted thiazolines and their intermediates | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-05-08 | — | — | US | disclosed |
| US-6545038-B1 | N-substituted 3-oxyaminocarbonyl-1,4-oxazonine or -thiazonine derivatives | THE PROCTER & GAMBLE COMPANY | 2003-04-08 | — | — | US | disclosed |
| EP-0925287-B1 | HETEROCYCLIC METALLOPROTEASE INHIBITORS | PROCTER & GAMBLE (US) | 2003-01-15 | — | — | EP | disclosed |
| US-6166005-A | Heterocyclic metalloprotease inhibitors | THE PROCTER & GAMBLE COMPANY | 2000-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186958-A1 | Heterocyclic metalloprotease inhibitors | MMP9, ADAM17, ADAM9 | ALDH1A1 445/4885USP2 1178/4885GAA 86/4885 |
| US-20030088105-A1 | Process for the preparation of substituted thiazolines and their intermediates | CBR1, RCOR1, MT-CO1 | ALDH1A1 106/4885USP2 4088/4885GAA 4272/4885 |
| US-20080026984-A1 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | MPO, TNF, AOX1 | ALDH1A1 7/4885USP2 1486/4885GAA 68/4885 |
| US-20070112216-A1 | Method for producing chiral mercapto amino acids | CPN1, AKR1C3, AHCY | ALDH1A1 605/4885USP2 908/4885GAA 2457/4885 |
| US-20050101782-A1 | Process for the preparation of substituted thiazolines and their intermediates | CBR1, CBR3, MT-CO1 | ALDH1A1 95/4885USP2 3824/4885GAA 4275/4885 |
| US-20070219120-A1 | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof | MPO, TNF, AOX1 | ALDH1A1 7/4885USP2 1486/4885GAA 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.