Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18617523 | 0.85 | NAMPT (0.57) | NAMPTROCK2ROCK1ALDH1A1LMNA | |
| SCHEMBL20672116 | 0.80 | LMNA (0.54) | NAMPTEPHX2NR1H4MEN1KMT2A | |
| SCHEMBL2007932 | 0.79 | EPHX2 (0.51) | NAMPTROCK2EPHX2NR1H4MEN1 | |
| SCHEMBL20672115 | 0.78 | GAA (0.62) | ROCK2EPHX2NR1H4MEN1KMT2A | |
| SCHEMBL20672114 | 0.77 | EPHX2 (0.50) | ROCK2EPHX2NR1H4MEN1KMT2A | |
| SCHEMBL20671968 | 0.76 | HPGDS (0.47) | NAMPTEPHX2NR1H4MEN1KMT2A | |
| SCHEMBL20671967 | 0.75 | HDAC3 (0.53) | ROCK2EPHX2NR1H4MEN1KMT2A | |
| SCHEMBL20233602 | 0.74 | NAMPT (0.48) | NAMPTHDAC6 | |
| SCHEMBL15873800 | 0.74 | L3MBTL1 (0.58) | NAMPTROCK2EPHX2NR1H4MEN1 | |
| SCHEMBL17293023 | 0.73 | NAMPT (0.51) | NAMPTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407422-B2 | Triazolopyridine inhibitors of myeloperoxidase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-10 | — | — | US | disclosed |
| US-20190023701-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL MYERS SQUIBB CO (US) | 2019-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190023701-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | EPX, MPO, SERPINB1 | NAMPT 1047/4885ROCK2 3068/4885EPHX2 28/4885 |
| US-10407422-B2 | Triazolopyridine inhibitors of myeloperoxidase | EPX, MPO, SERPINB1 | NAMPT 1047/4885ROCK2 3068/4885EPHX2 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.