Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Tribromoacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.39 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL108536 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL96619 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL1332461 | 0.84 | — | — | |
| Tribromoacetic Acid SCHEMBL2076262 | 0.84 | — | — | |
| Tribromoacetic Acid SCHEMBL9710919 | 0.84 | — | — | |
| Potassium Ion SCHEMBL28700682 | 0.81 | CA4 (0.44) | CA4FAHD1MEN1LDHABLM | |
| Trifluoroacetic Acid SCHEMBL31484359 | 0.81 | CA4 (0.43) | CA4FAHD1MEN1LDHABLM | |
| Trifluoroacetic Acid SCHEMBL29424398 | 0.81 | CA4 (0.43) | CA4FAHD1MEN1LDHABLM | |
| Trifluoroacetic Acid SCHEMBL3363842 | 0.81 | CA4 (0.43) | CA4FAHD1MEN1LDHABLM | |
| Trifluoroacetic Acid SCHEMBL3920984 | 0.81 | CA4 (0.40) | CA4FAHD1MEN1LDHABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012303-A1 | CLEAN, HIGH-YIELD PREPARATION OF S,S AND R,S AMINO ACID ISOSTERES | AEROJET FINE CHEMICALS LLC (US) | 2009-01-08 | — | — | US | claimed |
| US-6867311-B2 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | AEROJET FINE CHEMICALS LLC (US) | 2005-03-15 | — | — | US | claimed |
| US-20030225292-A1 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | AEROJET FINE CHEMICALS LLC, A DELAWARE LIMITED LIABILITY COMPANY | 2003-12-04 | — | — | US | claimed |
| US-20130116457-A1 | CLEAN, HIGH-YIELD PREPARATION OF S,S AND R,S AMINO ACID ISOSTERES | AEROJET FINE CHEMICALS LLC (US) | 2013-05-09 | — | — | US | disclosed |
| US-8163933-B2 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | AMPAC FINE CHEMICALS LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090012303-A1 | CLEAN, HIGH-YIELD PREPARATION OF S,S AND R,S AMINO ACID ISOSTERES | AEROJET FINE CHEMICALS LLC (US) | 2009-01-08 | — | — | US | disclosed |
| US-7309803-B2 | Clean, High-yield preparation of S,S and R,S amino acid isosteres | AEROJET FINE CHEMICALS LLC (US) | 2007-12-18 | — | — | US | disclosed |
| US-20050171170-A1 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | AEROJET FINE CHEMICALS LLC, A DELAWARE LIMITED LIABILITY COMPANY (US) | 2005-08-04 | — | — | US | disclosed |
| US-6867311-B2 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | AEROJET FINE CHEMICALS LLC (US) | 2005-03-15 | — | — | US | disclosed |
| US-20030225292-A1 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | AEROJET FINE CHEMICALS LLC, A DELAWARE LIMITED LIABILITY COMPANY | 2003-12-04 | — | — | US | disclosed |
| US-6605732-B1 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | AEROJET FINE CHEMICALS LLC | 2003-08-12 | — | — | US | disclosed |
| EP-1050532-A2 | Preparation of S,S and R,S amino acid isosteres | Aerojet Fine Chemicals LLC (US) | 2000-11-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012303-A1 | CLEAN, HIGH-YIELD PREPARATION OF S,S AND R,S AMINO ACID ISOSTERES | SRMS, HCK, BHMT2 | CA4 4042/4885FAHD1 3031/4885MEN1 2911/4885 |
| US-20050171170-A1 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | SRMS, HCK, BHMT2 | CA4 3919/4885FAHD1 2941/4885MEN1 2891/4885 |
| US-20130116457-A1 | CLEAN, HIGH-YIELD PREPARATION OF S,S AND R,S AMINO ACID ISOSTERES | SRMS, HCK, BHMT2 | CA4 4042/4885FAHD1 3031/4885MEN1 2911/4885 |
| US-20030225292-A1 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | SRMS, HCK, BHMT2 | CA4 3919/4885FAHD1 2941/4885MEN1 2891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.