SCHEMBL20920183

SCHEMBL20920183

CC1=CC([Si](C)(C)Cc2ccccc2)c2ccccc21

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 3/20 0.33
NPC1 O15118 3/20 0.32
RAB9A P51151 3/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
HPGD P15428 2/20 0.32
MAPK1 P28482 3/20 0.31
TDP1 Q9NUW8 2/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MAPT P10636 2/20 0.30
MEN1 O00255 1/20 0.30
TSHR P16473 1/20 0.30
KMT2A Q03164 1/20 0.30
BRD4 O60885 1/20 0.30
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21373216 0.83 MEN1 (0.32) HTR6MAPK1MAPTMEN1TSHR
SCHEMBL7542646 0.77 GPR3 (0.34) NPC1RAB9ASMN1; SMN2TDP1MEN1
SCHEMBL7936607 0.77 GPR3 (0.34) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL20996628 0.74 GPR3 (0.32) NPC1RAB9ASMN1; SMN2
SCHEMBL21029022 0.74 MEN1 (0.33) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL30307362 0.74 GPR3 (0.32) NPC1RAB9ASMN1; SMN2
SCHEMBL7944622 0.71 GPR3 (0.34)
SCHEMBL17296060 0.69 SIGMAR1 (0.40) HTR6SMN1; SMN2MEN1KMT2A
SCHEMBL7632634 0.68
SCHEMBL20996282 0.67 PTPN1 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3543262-B1 MULTI-COMPONENT COPOLYMER, RUBBER COMPOSITION, CROSSLINKED RUBBER COMPOSITION AND RUBBER PRODUCT BRIDGESTONE CORP (JP) 2025-02-26 EP disclosed
EP-3699204-B1 MULTI-COPOLYMER, RUBBER COMPOSITION, CROSS-LINKED RUBBER COMPOSITION, RUBBER ARTICLE, AND TIRE BRIDGESTONE CORP (JP) 2024-12-25 EP disclosed
EP-3904445-A1 TIRE RUBBER COMPOSITION AND TIRE Sumitomo Rubber Industries, Ltd. (JP) 2021-11-03 EP disclosed
US-11142606-B2 Multicomponent copolymer, rubber composition, crosslinked rubber composition and rubber product BRIDGESTONE CORPORATION (JP) 2021-10-12 US disclosed
EP-3699204-A1 MULTI-COPOLYMER, RUBBER COMPOSITION, CROSS-LINKED RUBBER COMPOSITION, RUBBER ARTICLE, AND TIRE Bridgestone Corporation (JP) 2020-08-26 EP disclosed
US-20200239675-A1 MULTI-COPOLYMER, RUBBER COMPOSITION, CROSS-LINKED RUBBER COMPOSITION, RUBBER ARTICLE, AND TIRE BRIDGESTONE CORPORATION (JP) 2020-07-30 US disclosed
CN-111247177-A Multipolymer, rubber composition, crosslinked rubber composition, rubber product and tire 株式会社普利司通 2020-06-05 CN disclosed
EP-3543262-A1 MULTI-COMPONENT COPOLYMER, RUBBER COMPOSITION, CROSSLINKED RUBBER COMPOSITION AND RUBBER PRODUCT Bridgestone Corporation (JP) 2019-09-25 EP disclosed
WO-2019078083-A1 MULTI-COPOLYMER, RUBBER COMPOSITION, CROSS-LINKED RUBBER COMPOSITION, RUBBER ARTICLE, AND TIRE 株式会社ブリヂストン 2019-04-25 WO disclosed