SCHEMBL21029022

SCHEMBL21029022

CC1=CC([Si](C)(C)O)c2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
ATM Q13315 1/20 0.33
GPR3 P46089 1/20 0.32
NPC1 O15118 3/20 0.32
RAB9A P51151 3/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
PKM P14618 2/20 0.32
EPHX2 P34913 1/20 0.32
TP53 P04637 1/20 0.32
STAT3 P40763 1/20 0.32
STAT1 P42224 1/20 0.32
POLB P06746 1/20 0.32
CASP3 P42574 1/20 0.31
SENP8 Q96LD8 1/20 0.31
SENP7 Q9BQF6 1/20 0.31
SENP6 Q9GZR1 1/20 0.31
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7542646 0.84 GPR3 (0.34) MEN1KMT2AATMGPR3NPC1
SCHEMBL7936607 0.84 GPR3 (0.34) MEN1KMT2AATMGPR3NPC1
SCHEMBL30307362 0.81 GPR3 (0.32) GPR3NPC1RAB9ASMN1; SMN2CASP3
SCHEMBL20996628 0.81 GPR3 (0.32) GPR3NPC1RAB9ASMN1; SMN2CASP3
SCHEMBL7944622 0.78 GPR3 (0.34) GPR3POLB
SCHEMBL21034911 0.77 PTPN1 (0.37) MEN1KMT2AATMPOLB
SCHEMBL7632634 0.74
SCHEMBL20920183 0.74 HTR6 (0.33) MEN1KMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL30084515 0.73 PTPN1 (0.34)
SCHEMBL21034568 0.73 TSHR (0.36) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10882925-B2 Catalysts that produce polyethylene with broad, bimodal molecular weight distribution EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-01-05 US disclosed
US-20190161561-A1 Catalysts that Produce Polyethylene with Broad, Bimodal Molecular Weight Distribution EXXONMOBIL CHEMICAL PATENTS INC. 2019-05-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10882925-B2 Catalysts that produce polyethylene with broad, bimodal molecular weight distribution RPLP0, RPSA, RPS10 MEN1 1400/4885KMT2A 222/4885ATM 1695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.