Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 16/20 | 0.54 |
| ▸ | ABCC9 | O60706 | 7/20 | 0.54 |
| ▸ | ABCC8 | Q09428 | 7/20 | 0.54 |
| ▸ | KCNJ8 | Q15842 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593291 | 0.83 | KDM4E (0.66) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL22451771 | 0.80 | ACE2 (0.50) | KCNJ11ABCC9ABCC8KCNJ8MEN1 | |
| SCHEMBL16852472 | 0.77 | KDM4E (0.54) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL14593292 | 0.75 | KDM4E (0.57) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL5682891 | 0.74 | GABRA1 (0.43) | ALDH1A1ATMHTT | |
| SCHEMBL30537735 | 0.74 | GABRA1 (0.43) | ALDH1A1ATMHTT | |
| SCHEMBL19606079 | 0.74 | AR (0.44) | KCNJ11ABCC9ABCC8KCNJ8MEN1 | |
| SCHEMBL17711245 | 0.73 | KDM4E (0.54) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL18077903 | 0.73 | KDM4E (0.54) | KCNJ11ABCC9ABCC8KCNJ8KDM4E | |
| SCHEMBL17298377 | 0.72 | KCNJ11 (0.50) | KCNJ11ABCC9ABCC8KCNJ8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301272-B2 | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] | PHENEX PHARMACEUTICALS AG (DE) | 2019-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10301272-B2 | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] | RORA, RORB, RORC | KCNJ11 4190/4885ABCC9 2014/4885ABCC8 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.