SCHEMBL2106403

SCHEMBL2106403

NC1CCCN(C(=O)O)CC1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.41
CHRM1 P11229 2/20 0.41
CHRM3 P20309 2/20 0.41
GNAI3 P08754 1/20 0.40
GNAO1 P09471 1/20 0.40
GNAI1 P63096 1/20 0.40
CACNA1B Q00975 2/20 0.36
HPGD P15428 1/20 0.35
KDM1A O60341 1/20 0.33
DPP4 P27487 3/20 0.33
L3MBTL3 Q96JM7 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
DPP7 Q9UHL4 2/20 0.33
CPN1 P15169 1/20 0.32
CPB2 Q96IY4 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
TFPI2 P48307 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3618718 1.00 CHRM2 (0.41) CHRM2CHRM1CHRM3GNAI3GNAO1
SCHEMBL15101461 1.00 CHRM2 (0.41) CHRM2CHRM1CHRM3GNAI3GNAO1
SCHEMBL4697949 0.96 HPGD (0.38) CHRM2CHRM1CHRM3GNAI3GNAO1
SCHEMBL112479 0.91 GNAI3 (0.44) CHRM2CHRM1CHRM3GNAI3GNAO1
Hydrochloric Acid SCHEMBL4593370 0.89 GNAI3 (0.47) CHRM2CHRM1CHRM3GNAI3GNAO1
SCHEMBL1421166 0.83 HPGD (0.35) HPGDKDM1ACPN1CPB2ALDH1A1
SCHEMBL477321 0.83 HPGD (0.35) HPGDKDM1ACPN1CPB2ALDH1A1
SCHEMBL1248249 0.83 HPGD (0.35) HPGDKDM1ACPN1CPB2ALDH1A1
SCHEMBL14275857 0.81 EPHX2 (0.46) CHRM2CHRM1CHRM3GNAI3GNAO1
Hydrochloric Acid SCHEMBL3487633 0.81 KDM1A (0.34) HPGDKDM1ACPN1CPB2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115991706-A PIM kinase inhibitors 杭州邦顺制药有限公司 2023-04-21 CN disclosed
US-20220389019-A1 TrkB POSITIVE ALLOSTERIC MODULATORS INSERM - INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (FR) 2022-12-08 US disclosed
EP-4010341-A1 TRKB POSITIVE ALLOSTERIC MODULATORS Université de Strasbourg (FR) 2022-06-15 EP disclosed
US-20220023281-A1 HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS THE UNIVERSITY OF SHEFFIELD (GB) 2022-01-27 US disclosed
EP-3880679-A1 HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS The University Of Sheffield (GB) 2021-09-22 EP disclosed
WO-2021023858-A1 TrkB POSITIVE ALLOSTERIC MODULATORS UNIVERSITÉ DE STRASBOURG (FR) 2021-02-11 WO disclosed
WO-2020099882-A1 HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS THE UNIVERSITY OF SHEFFIELD (GB) 2020-05-22 WO disclosed
EP-2780015-A1 MUSCARINIC M1 RECEPTOR AGONISTS Heptares Therapeutics Limited (GB) 2014-09-24 EP disclosed
CN-103483317-A Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme ABBVIE INC 2014-01-01 CN disclosed
WO-2013072705-A1 MUSCARINIC M1 RECEPTOR AGONISTS HEPTARES THERAPEUTICS LIMITED (GB) 2013-05-23 WO disclosed
US-20100016291-A1 MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2010-01-21 US disclosed
WO-2009091856-A2 BETA-LACTAMASE INHIBITORS MERCK & CO., INC. (US) 2009-07-23 WO disclosed
EP-2076487-A1 MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2009-07-08 EP disclosed
EP-2057141-A1 PYRIMIDONE COMPOUNDS AS GSK-3 INHIBITORS Pfizer Products Inc. (US) 2009-05-13 EP disclosed
CN-101415675-A 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors ABBOTT LAB (US) 2009-04-22 CN disclosed
EP-2007719-A2 INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME Abbott Laboratories (US) 2008-12-31 EP disclosed
WO-2008049808-A1 MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2008-05-02 WO disclosed
WO-2008023239-A1 PYRIMIDONE COMPOUNDS AS GSK-3 INHIBITORS PFIZER PRODUCTS INC. (US) 2008-02-28 WO disclosed
US-20070293477-A1 Novel Compounds SMITHKLINE BEECHAM CORPORATION 2007-12-20 US disclosed
WO-2007118185-A2 INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME ABBOTT LABORATORIES (US) 2007-10-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016291-A1 MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES PNLIP, APOB, MTPN CHRM2 4474/4885CHRM1 4355/4885CHRM3 4652/4885
US-20220389019-A1 TrkB POSITIVE ALLOSTERIC MODULATORS HTT, NTRK2, BDNF CHRM2 1374/4885CHRM1 1285/4885CHRM3 1156/4885
US-20070293477-A1 Novel Compounds HRH4, TRPV4, TRPC4 CHRM2 234/4885CHRM1 180/4885CHRM3 128/4885
US-20220023281-A1 HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS MC2R, AGTR2, AGTR1 CHRM2 27/4885CHRM1 47/4885CHRM3 126/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.