Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 5/20 | 0.37 |
| ▸ | APLNR | P35414 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22388850 | 0.84 | ESR1 (0.43) | ESR1ESR2APLNRJAK2JAK3 | |
| SCHEMBL18811782 | 0.79 | ESR1 (0.37) | ESR1ESR2KCNH2 | |
| SCHEMBL22166866 | 0.78 | APLNR (0.40) | GPR55APLNRJAK2JAK3HDAC6 | |
| SCHEMBL19831132 | 0.76 | GPR55 (0.35) | ESR1ESR2GPR55GRM2 | |
| SCHEMBL22304261 | 0.74 | ESR1 (0.35) | ESR1ESR2APLNRJAK2JAK3 | |
| SCHEMBL21397356 | 0.73 | ESR1 (0.31) | ESR1ESR2 | |
| SCHEMBL21076611 | 0.73 | ESR1 (0.37) | ESR1ESR2KCNH2 | |
| SCHEMBL22895111 | 0.73 | NR3C2 (0.41) | ESR1ESR2HTR7 | |
| SCHEMBL23758345 | 0.72 | ALDH1A1 (0.34) | ESR1ESR2KCNH2 | |
| SCHEMBL18763535 | 0.71 | LMNA (0.42) | ESR1ESR2GPR55KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695348-B2 | Sulfonyl pyridyl TRP inhibitors | GENENTECH, INC. (US) | 2020-06-30 | — | — | US | disclosed |
| US-20190167681-A1 | SULFONYL PYRIDYL TRP INHIBITORS | GENENTECH, INC. (US) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10695348-B2 | Sulfonyl pyridyl TRP inhibitors | TRPA1, TRPV1, TRPV5 | ESR1 3955/4885ESR2 3977/4885GPR55 146/4885 |
| US-20190167681-A1 | SULFONYL PYRIDYL TRP INHIBITORS | TRPA1, TRPV1, TRPV5 | ESR1 3955/4885ESR2 3977/4885GPR55 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.