Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101771 | 0.79 | POLB (0.55) | POLBHTT | |
| SCHEMBL21101772 | 0.78 | BRD4 (0.49) | KMT2AMAPTPOLBBACE1ALDH1A1 | |
| SCHEMBL21101904 | 0.77 | ALDH1A1 (0.60) | KMT2AMAPTPOLBALDH1A1PKM | |
| SCHEMBL21101905 | 0.76 | ALPL (0.46) | POLBBACE1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL21101911 | 0.75 | KDM4E (0.43) | POLBBACE1ALDH1A1 | |
| SCHEMBL21102114 | 0.73 | LMNA (0.52) | KMT2AMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL21102111 | 0.71 | LMNA (0.59) | KMT2AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL21101906 | 0.71 | KDM4E (0.66) | KMT2AMAPTATMALDH1A1MEN1 | |
| SCHEMBL12678487 | 0.68 | ALDH1A1 (0.54) | POLBBACE1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL14414981 | 0.66 | KAT2B (0.55) | MAPTATMPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |