Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101906 | 0.78 | KDM4E (0.66) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL21102114 | 0.77 | LMNA (0.52) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL21102111 | 0.76 | LMNA (0.59) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL21101771 | 0.76 | POLB (0.55) | HTT | |
| SCHEMBL2706475 | 0.75 | TSHR (0.60) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL2706478 | 0.75 | TSHR (0.60) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL21101772 | 0.74 | BRD4 (0.49) | ALDH1A1MEN1KMT2AHTTLMNA | |
| SCHEMBL21101911 | 0.74 | KDM4E (0.43) | KDM4EALDH1A1LMNA | |
| SCHEMBL21101904 | 0.74 | ALDH1A1 (0.60) | ALDH1A1KMT2ALMNAL3MBTL1THRB | |
| SCHEMBL21101905 | 0.73 | ALPL (0.46) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |