Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 6/20 | 0.38 |
| ▸ | NOS2 | P35228 | 6/20 | 0.38 |
| ▸ | NOS3 | P29474 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13593518 | 0.93 | PNMT (0.42) | PNMTENPP2LOXL2NOS1NOS2 | |
| SCHEMBL13593566 | 0.90 | PNMT (0.38) | PNMTENPP2LOXL2NOS1NOS2 | |
| SCHEMBL13508600 | 0.89 | PNMT (0.45) | PNMTENPP2LOXL2NOS1NOS2 | |
| SCHEMBL27482090 | 0.87 | PNMT (0.38) | PNMTENPP2LOXL2NOS1NOS2 | |
| SCHEMBL24969886 | 0.83 | PRKCA (0.39) | ENPP2ESR1ESR2AOC3 | |
| SCHEMBL13092691 | 0.83 | PNMT (0.40) | PNMTENPP2LOXL2NOS1NOS2 | |
| SCHEMBL28106044 | 0.82 | LOXL2 (0.40) | PNMTENPP2LOXL2NOS1NOS2 | |
| SCHEMBL7976600 | 0.79 | KIF11 (0.40) | NOS1NOS2NOS3ALDH1A1CYP3A4 | |
| SCHEMBL1945278 | 0.79 | ENPP2 (0.44) | PNMTENPP2LOXL2NOS1NOS2 | |
| SCHEMBL19035317 | 0.79 | CPN1 (0.40) | ALDH1A1CYP3A4AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350208-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | ROIVANT SCIENCES GMBH (CH) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350208-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | TPH1, TPH2, HTR1A | PNMT 107/4885ENPP2 489/4885LOXL2 1549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.