Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036253 | 0.81 | DRD2 (0.46) | MAOAPOLBHTR2BMEN1TSHR | |
| SCHEMBL68228 | 0.77 | PNMT (0.49) | MAOAHTR2BCES1BCHEALDH1A1 | |
| SCHEMBL28004757 | 0.77 | MAOA (0.54) | MAOAPOLBHTR2BCES1BCHE | |
| SCHEMBL26982496 | 0.77 | CYP3A4 (0.44) | MAOAPOLBHTR2BCES1BCHE | |
| SCHEMBL28004759 | 0.74 | MAOA (0.52) | MAOAPOLBHTR2BCES1BCHE | |
| SCHEMBL30403300 | 0.74 | MAOA (0.56) | MAOAPOLBHTR2BCES1BCHE | |
| SCHEMBL1626146 | 0.74 | MAOA (0.52) | MAOAPOLBHTR2BCES1BCHE | |
| SCHEMBL29225584 | 0.73 | MAOA (0.47) | MAOAPOLBHTR2BCES1BCHE | |
| SCHEMBL3612896 | 0.73 | MEN1 (0.36) | MAOAPOLBCES1BCHEALDH1A1 | |
| SCHEMBL2526501 | 0.72 | HTR2B (0.45) | MAOAPOLBHTR2BCES1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190071407-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2019-03-07 | — | — | US | disclosed |
| US-10155730-B2 | Isoxazoline derivatives as insecticides | SYNGENTA CROP PROTECTION, LLC (US) | 2018-12-18 | — | — | US | disclosed |
| US-20160368883-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2016-12-22 | — | — | US | disclosed |
| EP-2536698-B1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-06-10 | — | — | EP | disclosed |
| US-20140178606-A1 | CELLULOSE ACYLATE FILM, POLARIZER, AND LIQUID CRYSTAL DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2014-06-26 | — | — | US | disclosed |
| US-8477275-B2 | Optical film and liquid crystal display device | FUJIFILM CORPORATION (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20130128359-A1 | OPTICAL FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY APPARATUS | FUJIFILM CORPORATION (JP) | 2013-05-23 | — | — | US | disclosed |
| WO-2013032016-A1 | CELLULOSE ACYLATE FILM, POLARIZER, AND LIQUID CRYSTAL DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2013-03-07 | — | — | WO | disclosed |
| US-20120092595-A1 | Optical film, polarizing plate and liquid crystal display device | FUJIFILM CORPORATION (JP) | 2012-04-19 | — | — | US | disclosed |
| US-20120092594-A1 | OPTICAL FILM AND LIQUID CRYSTAL DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2012-04-19 | — | — | US | disclosed |
| EP-0363212-B1 | Novel heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components | MITSUI TOATSU CHEMICALS (JP) | 1995-01-04 | — | — | EP | disclosed |
| WO-1994022842-A1 | 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE | BASF AKTIENGESELLSCHAFT (DE) | 1994-10-13 | — | — | WO | disclosed |
| EP-0601977-A1 | Aromatic hydroxyamidine derivatives and their use as leukotriene B4 receptor anagonists | CIBA-GEIGY AG (CH) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994011341-A1 | SUBSTITUTED AMIDINO COMPOUNDS, THEIR MANUFACTURE AND METHODS OF TREATMENT | CIBA-GEIGY AG (CH) | 1994-05-26 | — | — | WO | disclosed |
| US-5246965-A | Leukotriene antagonist | CIBA-GEIGY (US) | 1993-09-21 | — | — | US | disclosed |
| US-5204348-A | Quinoline derivatives | MITSUI TOATSU CHEMICALS INC. (JP) | 1993-04-20 | — | — | US | disclosed |
| EP-0518818-A2 | Arylethers, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |
| US-5112817-A | Anticancer Drug Potentiators | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1992-05-12 | — | — | US | disclosed |
| EP-0363212-A2 | Novel heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-04-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071407-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | ACHE, CHRM1, ITPR3 | MAOA 909/4885POLB 4453/4885HTR2B 1784/4885 |
| US-10155730-B2 | Isoxazoline derivatives as insecticides | ACHE, CHRM1, ITPR3 | MAOA 909/4885POLB 4453/4885HTR2B 1784/4885 |
| US-20160368883-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | ACHE, CHRM1, ITPR3 | MAOA 909/4885POLB 4453/4885HTR2B 1784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.