Sugi Predict

Sugi Predict / Compounds / SCHEMBL2138372

SCHEMBL2138372

SCHEMBL2138372

Fc1ccccc1-c1ccc(Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ APEX1 P27695 2/20 0.57
▸ CYP1A2 P05177 1/20 0.50
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ PTGS2 P35354 4/20 0.47
▸ PTGS1 P23219 2/20 0.47
▸ PTPRC P08575 1/20 0.47
▸ PTPN1 P18031 1/20 0.47
▸ NFE2L2 Q16236 1/20 0.44
▸ NPSR1 Q6W5P4 1/20 0.43
▸ SLC6A4 P31645 1/20 0.43
▸ SLC6A3 Q01959 1/20 0.43
▸ DHODH Q02127 1/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ CASP3 P42574 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ SENP8 Q96LD8 1/20 0.42
▸ SENP7 Q9BQF6 1/20 0.42
▸ SENP6 Q9GZR1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30278472 1.00 APEX1 (0.57) APEX1CYP1A2L3MBTL1ALDH1A1MAPT
SCHEMBL18488734 0.90 PTPRC (0.53) APEX1CYP1A2PTGS2PTGS1PTPRC
SCHEMBL12856701 0.87 PTPRC (0.56) APEX1L3MBTL1ALDH1A1MAPTPTPRC
SCHEMBL9862848 0.82 CYP1A2 (0.63) CYP1A2L3MBTL1ALDH1A1PTGS2PTGS1
Methane SCHEMBL27673420 0.80 CYP11B1 (0.44) APEX1CYP1A2L3MBTL1PTGS2PTGS1
SCHEMBL20898128 0.80 PTGS2 (0.58) APEX1CYP1A2PTGS2PTGS1PTPRC
SCHEMBL31067152 0.80 PTGS2 (0.58) APEX1CYP1A2PTGS2PTGS1PTPRC
SCHEMBL2140802 0.80 ALDH1A1 (0.50) CYP1A2L3MBTL1ALDH1A1MAPTPTPRC
SCHEMBL533630 0.80 PTGS2 (0.50) L3MBTL1ALDH1A1MAPTPTGS2PTGS1
SCHEMBL30543293 0.80 ALDH1A1 (0.50) CYP1A2L3MBTL1ALDH1A1MAPTPTPRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230068853-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2023-03-02 — — US disclosed
US-20230053362-A1 DICHROIC DYE COMPOSITION MERCK PATENT GMBH (DE) 2023-02-23 — — US disclosed
US-20210292652-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2021-09-23 — — US disclosed
US-11053442-B2 Liquid crystal mixture and liquid crystal display MERCK PATENT GMBH (DE) 2021-07-06 — — US disclosed
US-20210087469-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2021-03-25 — — US disclosed
US-20200255740-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2020-08-13 — — US disclosed
US-10738240-B2 Thiadiazoloquinoxaline derivatives MERCK PATENT GMBH (DE) 2020-08-11 — — US disclosed
US-10738243-B2 Liquid-crystalline medium and liquid-crystal display MERCK PATENT GMBH (DE) 2020-08-11 — — US disclosed
US-10626330-B2 Method for manufacturing a liquid crystal display device and liquid crystal mixture MERCK PATENT GMBH (DE) 2020-04-21 — — US disclosed
US-10570335-B2 Liquid crystal medium containing polymerisable compounds MERCK PATETN GMBH (DE) 2020-02-25 — — US disclosed
US-20170037315-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-02-09 — — US disclosed
US-8242278-B2 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-14 — — US disclosed
US-20120101278-A1 PROCESS FOR PRODUCING BIARYL COMPOUND HAGIYA KOJI (JP) 2012-04-26 — — US disclosed
EP-1473286-B1 PROCESS FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL CO (JP) 2009-11-04 — — EP disclosed
US-20090216017-A1 PROCESS FOR PRODUCING BIARYL COMPOUND HAGIYA KOJI 2009-08-27 — — US disclosed
US-7554000-B2 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-30 — — US disclosed
US-7414063-B2 Inhibitors of Akt (protein kinase B) ELI LILLY AND COMPANY (US) 2008-08-19 — — US disclosed
US-20070043040-A1 Inhibitors of akt (protein kinase b) ELI LILLY AND COMPANY 2007-02-22 — — US disclosed
US-20050096471-A1 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-05-05 — — US disclosed
EP-1473286-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10626330-B2 Method for manufacturing a liquid crystal display device and liquid crystal mixture MAP1LC3C, MAP1LC3A, MAP1LC3B APEX1 2800/4885CYP1A2 2695/4885L3MBTL1 736/4885
US-20120101278-A1 PROCESS FOR PRODUCING BIARYL COMPOUND PPOX, CAT, TYR APEX1 440/4885CYP1A2 19/4885L3MBTL1 4001/4885
US-20070043040-A1 Inhibitors of akt (protein kinase b) AKT1, AKT2, BRAF APEX1 4077/4885CYP1A2 3491/4885L3MBTL1 1339/4885
US-20230068853-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY CXCR1, PYM1, F11 APEX1 2451/4885CYP1A2 541/4885L3MBTL1 411/4885
US-20090216017-A1 PROCESS FOR PRODUCING BIARYL COMPOUND PPOX, CAT, TYR APEX1 440/4885CYP1A2 19/4885L3MBTL1 4001/4885
US-20050096471-A1 Process for producing biaryl compound PPOX, CAT, TYR APEX1 440/4885CYP1A2 19/4885L3MBTL1 4001/4885
US-20210292652-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY CXCR1, PYM1, F11 APEX1 2272/4885CYP1A2 786/4885L3MBTL1 370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.