Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 13/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390820 | 0.98 | ACSS2 (0.33) | ACSS2PPARGIDH1HDAC3HDAC4 | |
| SCHEMBL21390884 | 0.89 | BRD4 (0.33) | IDH1HDAC3PTGS1HDAC4HDAC1 | |
| SCHEMBL21390957 | 0.85 | NTRK1 (0.33) | ACSS2PPARGHDAC3HDAC4HDAC1 | |
| SCHEMBL21390925 | 0.85 | HPGDS (0.34) | IDH1HDAC3PTGS1HDAC4HDAC1 | |
| SCHEMBL21390812 | 0.85 | PDE4A (0.30) | — | |
| SCHEMBL21391052 | 0.85 | ACSS2 (0.36) | ACSS2PPARGGRM2 | |
| SCHEMBL21391043 | 0.82 | ACSS2 (0.41) | ACSS2 | |
| SCHEMBL21390961 | 0.82 | — | — | |
| SCHEMBL21390958 | 0.82 | — | — | |
| SCHEMBL20111113 | 0.81 | ACSS2 (0.38) | ACSS2IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |